Pharmaceutical formulation for slow release via controlled surface erosion
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United States of America Patent
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-
Apr 28, 1981
Grant Date -
N/A
app pub date -
May 21, 1979
filing date -
May 21, 1979
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A pharmaceutical composition in tablet form for oral administration comprises: (a) 30-90% by weight of an active ingredient having a water solubility (20.degree. C.) of about 1/10-1/500 (w/w); (b) 1-40% by weight of an excipient which is pharmaceutically acceptable in oral tablets and which has a water solubility (20.degree. C.) of about 1/1-1/20 (w/w); (c) 0-20% by weight of a binder which is pharmaceutically acceptable in oral tablets; (d) 0-50% by weight of an excipient which is pharmaceutically acceptable in oral tablets and which has a water solubility (20.degree. C.) of about 1/1-1/5 (w/w); (e) 0.5-5% by weight of a die wall lubricant pharmaceutically acceptable in oral tablets; (f) 0-5% by weight of a surface active agent pharmaceutically acceptable in oral tablets; and (g) 0-1.0% by weight of a disintegration agent pharmaceutically acceptable in oral tablets; whereby the active ingredient has a slow in vivo release rate due to controlled surface erosion of the tablet.
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