Matansinol 3-n-hexadecanoate
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United States of America Patent
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-
May 5, 1981
Grant Date -
N/A
app pub date -
Mar 19, 1979
filing date -
Mar 24, 1978
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Maytansinoids of the formula: ##STR1## wherein R is hydrogen or alkyl of 1 to 15 carbon atoms are produced by contacting, in the presence of a carbodiimide, maytansinol with a carboxylic acid of the formula: R--COOH wherein R has the same meaning as defined above. In accordance with a second aspect of the invention there are provided novel maytansinoids of the formula ##STR2## wherein R' is hydrogen, n-butyl or alkyl of 5 to 15 carbon atoms.
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