N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives

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United States of America Patent

PATENT NO 4269843
SERIAL NO

06166948

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Abstract

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Novel N-sec-alkyl derivatives of norcodeine and normorphine wherein the sec-alkyl group contains either four or five carbon atoms. Specifically included are those derivatives of norcodeine and normorphine wherein the sec-alkyl group is 2-butyl, 3-pentyl, .alpha.-methylallyl and .alpha.-methylcyclopropylmethyl. The normorphine derivatives having strong agonist potency combined with strong antagonist qualities and indicated low addiction potential. The norcodeine analogs are useful as intermediates in preparing the corresponding normorphine compounds.

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Patent Owner(s)

Patent OwnerAddress
SRI INTERNATIONALMENLO PARK CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Graw Joseph I Sunnyvale, CA 2 44
Johnson, Howard L Sunnyvale, CA 15 146
Lawson, John A Monte Vista, CA 23 354
Loew, Gilda H Atherton, CA 4 38

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