In vivo inhibitors of cholesterol biosynthesis
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United States of America Patent
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-
Jul 21, 1981
Grant Date -
N/A
app pub date -
Apr 22, 1980
filing date -
Apr 22, 1980
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Dialkyl esters of 5-carbo[etiocholane-3'.alpha.-7'.alpha., 12'.alpha.-trihydroxy-17'.beta.(1' methyl-4' butyl]oxy-4-hydroxy-4-methylpentyl-1-phosphonate and 5-carbohexadecyloxy-4-hydroxy-4-methylpentyl-1-phosphonate are shown to inhibit cholesterol biosynthesis in rat liver cells. Preparation of the active compounds is given.
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