Bone morphogenetic protein process
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United States of America Patent
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Oct 13, 1981
Grant Date -
N/A
app pub date -
Aug 4, 1980
filing date -
Aug 4, 1980
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The process of separating bone morphogenetic protein (BMP) from bone tissue comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the group consisting of urea and guanidine, and thereby transforming the bone collagen to gelatin and extracting BMP into the solution of solubilizing agent; and separating the solubilizing agent and neutral salt from the solution, thereby precipitating BMP in the aqueous medium.
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