Assay for mutagenesis in bacterial cells
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United States of America Patent
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-
Nov 10, 1981
Grant Date -
N/A
app pub date -
Oct 17, 1977
filing date -
Oct 17, 1977
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to bacterial cells such as Salmonella typhimurium. After administration of or exposure to a mutagenic agent, the bacterial cells are plated in the presence of a purine analog and resistance to purine analogs is used as the genetic marker. This bioassay system can be used by genetic toxicologists to determine the potential genetic hazards from the use of a variety of suspected or known mutagens, including newly-developed chemicals.
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