Assay for mutagenesis in heterozygous diploid human lymphoblasts

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United States of America Patent

PATENT NO 4302535
SERIAL NO

06079549

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Abstract

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An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cytidine deaminase. Since human lymphoblastoid cells contain two genes for these enzymes, heterozygotes of human lymphoblastoid cells are used in this assay.

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Patent Owner(s)

  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY;CAMBRIDGE RESEARCH AND DEVELOPMENT GROUP

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hoppe, IV Henry Arlington, MA 3 50
Liber, Howard L Brookline, MA 1 14
Penman, Bruce W Cambridge, MA 3 44
Skopek, Thomas R Somerville, MA 3 21
Thilly, William G Cambridge, MA 29 332

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