Metal sol particle immunoassay
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United States of America Patent
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-
Feb 2, 1982
Grant Date -
N/A
app pub date -
Jul 13, 1979
filing date -
Jul 13, 1978
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method, test kit and labeled component for the detection and/or determination of one or more components of the reaction between a specific binding protein and the corresponding bindable substance, in which one or more labelled components are used, that are obtained by coupling particles of a dispersion of a metal, metal compound or polymer nuclei, coated with a metal or metal compound, having a particle size of at least 5 nm, directly or indirectly to the desired component of said reaction. During the reaction or after an adequate reaction time, the physical properties and/or the amount of the metal and/or the formed metal containing agglomerate, is/are determined in the test sample, or optionally after a separation of the bound and free metal-labelled components in one of the derived fractions by methods known as known by those skilled in the immunoassay field.
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