Extended N-terminal somatostatin

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United States of America Patent

PATENT NO 4316891
SERIAL NO

06159801

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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28-member residue and 25-member residue peptides have been synthesized containing the tetradecapeptide somatostatin that are more potent than somatostatin. Somatostatin-28 has the formula: ##STR1## The three N-terminal amino acid residues are absent in somatostatin-25. Somatostatin-28 or somatostatin-25 or a pharmaceutically acceptable addition salt thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals in the same manner as somatostatin.

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Patent Owner(s)

  • SALK INSTITUTE FOR BIOLOGICAL STUDIES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bohlen, Peter Encinitas, CA 36 769
Brazeau, Jr Paul E San Diego, CA 5 139
Esch, Fred S San Diego, CA 2 81
Guillemin, Roger C L La Jolla, CA 10 297
Ling, Nicholas C San Diego, CA 19 499

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