Fractionation of protein mixtures

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United States of America Patent

PATENT NO 4322275
SERIAL NO

06197394

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Abstract

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This invention relates to the separation of complex protein mixtures by lowering (desalting) or by raising (salting-out) their electrolytic (ionic) concentration by electrodialysis followed by chilling, pH adjustment, filtration, and/or centrifugation and optionally thereafter restoration of the lost electrolyte or removal of the gained electrolyte and water. This technique is especially adaptable for therapeutic plasma exchange performed in situ for immunepheresis i.e. removal of globulin or immunecomplexes implicated in autoimmune diseases. The techniques are also applicable for antihemophilic factor separation and purification, and separation of proteins from whey.

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Patent Owner(s)

Patent OwnerAddress
IONICS INCORPORATED65 GROVE STREET WATERTOWN MA 02472

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jain, Surendar M Watertown, MA 9 255

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