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Abstract

Pharmaceutical compositions having anti-ulcer activity, containing as an active ingredient a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Het is a heteroaromatic group (substituted or unsubstituted), containing one or more nitrogen atoms as hetero atoms and no more than two rings; X is a hydrogen atom or a cyano, trifluoromethyl or an amido group with the formula--C(A)NR.sup.1 R.sup.2, wherein A is oxygen or sulphur, R.sup.1 is hydrogen or a C.sub.1-4 alkyl group, R.sup.2 is hydrogen or a C.sub.1-4 alkyl group, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a 5- to 6-membered heterocyclic ring in which another hetero atom may be present; and R is C.sub.1-6 alkyl, C.sub.5-6 cycloalkyl, C.sub.5-8 cycloalkylalkyl, C.sub.3-6 alkenyl, C.sub.3-4 alkynyl, phenyl C.sub.1-3 alkyl, the phenyl group being optionally substituted by one or more C.sub.1-6 alkyl, halogen, C.sub.1-6 alkoxy, nitro, cyano or trifluoromethyl groups, a carbamidoalkyl group with the formula--(CH.sub.2).sub.m C(O)NR.sup.3 R.sup.4 wherein m=1 or 2, R.sup.3 is hydrogen or C.sub.1-3 alkyl, R.sup.4 is hydrogen or C.sub.1-3 alkyl, or R.sup.3 and R.sup.4 together with the nitrogen atom to which they are attached form a 5- to 6-membered heterocyclic ring in which another hetero atom may be present, or cyano C.sub.1-3 alkyl; or an N-oxide or pharmaceutically acceptable salt thereof; novel compounds of the said formula and methods for preparing these compounds.

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First Claim