Easily split substrates for the quantification of proteases
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United States of America Patent
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Jun 15, 1982
Issued Date -
N/A
app pub date -
Mar 25, 1981
filing date -
Feb 7, 1978
priority date (Note) -
Expired
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Abstract
Easily split enzyme substrates for the quantification of proteases having the general formula R.sub.1 --p-Glu--A.sub.1 --A.sub.2 --NH--R.sub.2, where R.sub.1 =H or a protective group, preferably t-butyloxycarbonyl, benzyloxycarbonyl; A.sub.1 =Gly, Ala, Val, Leu, Ile, Ser, Thr, Pro, Pip, Phe or Tyr; A.sub.2 =Arg or Lys; R.sub.2 =an aromatic, possibly substituted, hydrocarbon group, wherein --NH--R.sub.2 is a physico-chemically determinable group, preferably a chromogenic or fluorogenic group which is split by a present enzyme and then forms a cleavage product of the formula H.sub.2 N--R.sub.2 the amount of which can be quantified. Processes for the production of said substrates. Method in the laboratory diagnostics of proteases using said substrates.
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