Method of delivering a therapeutic agent to a target capillary bed
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United States of America Patent
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Aug 24, 1982
Issued Date -
N/A
app pub date -
Jun 27, 1980
filing date -
Apr 23, 1979
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Intravascularly-administrable, magnetically-localizable biodegradable microspheres containing a therapeutic agent, such as an oncolytic agent, are prepared and administered so that they can be permanently localized in a target capillary bed for release of the therapeutic agent therein. The effects of the therapeutic agent can thereby be relatively confined to the area of the capillary bed. Of particular importance is the administration of oncolytic agents by the method, since this permits the undesirable side effects of the oncolytic agents to be substantially reduced, while at the same time increasing the anti-cancer effectiveness of the drug.
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