Process for the preparation of a mixture of an anti-inflammatory steroid and a fluoro-chloro-hydrocarbon to be used as a propellant
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United States of America Patent
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Aug 31, 1982
Grant Date -
N/A
app pub date -
May 19, 1981
filing date -
May 19, 1980
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A process by means of which an increase in the particle size of a micro-ground anti-inflammatory steroid in the aerosol propellant is prevented. The increase in the particle size is prevented at the suspending stage when the solubility of the steroid into the propellant is reduced by using a low temperature and by initially mixing only a little quantity of the propellant with the steroid. If desired, the smallest and dissolved steroid particles can be removed by filtering. The particle size does not become larger even afterwards when the suspension is allowed to be stabilized for a sufficiently long time before the temperature is raised or the rest of the propellant is added.
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