Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
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United States of America Patent
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-
Sep 7, 1982
Grant Date -
N/A
app pub date -
Oct 7, 1981
filing date -
Oct 17, 1980
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A pharmaceutical composition suitable for the treatment and prophylaxis of hemophilia A or B, which comprises coagulation factor VIII or IX and a protease inhibitor (particularly aprotinin) which are incorporated in liposomes and optionally lyophilized and/or encapsulated in intestine capsules. The composition can give high absorption of the required coagulation factor from intestinal tract without being decomposed in gastrointestinal tract even by administration in oral route.
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