Importance

Loading Importance Indicators...

Abstract

The invention relates to the method of preparation of N-glycosyl compounds of anthracyclin antibiotics of formula I ##STR1## where R.sub.1 is the hydrogen atom or hydroxylic group, whereas R.sub.2 is the residue of a mono- or oligosaccharide of a series of aldeses and ketoses or the derivatives reacted with the amine group of the antibiotic. The invention depends upon the reaction of the antibiotic, which is converted into the form of base, in an organic solvent by treatment with molar excess of the saccharide or its derivative at temperature from 20.degree. up to 60.degree. C., for several hours, in the presence of a catalyst, under continuous stirring. The product is precipitated from the reaction mixture upon the addition of a nonpolar solvent and subsequently is purified by known methods.

Loading the Abstract Image...

First Claim