Carrier base material for prolonged release therapeutic compositions
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United States of America Patent
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Nov 2, 1982
Issued Date -
N/A
app pub date -
Jun 29, 1981
filing date -
Jun 14, 1979
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A carrier base material adapted to be combined with a therapeutically active medicament and shaped and compressed to form a sustained release therapeutic composition having a long-lasting, slow and regular incremental release of the medicament upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and either up to 30% ethylcellulose or 30% sodium carboxymethylcellulose or both, and wherein the carrier base material has been subjected to hydrolysis and oxidation successively or concurrently until the carbonyl content ranges from 0.2-3.0 grams/100 grams, the carboxyl content ranges from 0.60-2.60 grams/100 grams and the moisture content is in the range of 0.5-3.9%.
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