US Patent No: 4,358,535

Number of patents in Portfolio can not be more than 2000

Specific DNA probes in diagnostic microbiology

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Abstract

Method and compositions for infectious disease diagnosis and epidemiology involving labeled nucleotide probes complementary to nucleic acid coding for a characteristic pathogen product. Clinical isolates are cultivated, expanding the number of microorganisms, the resulting colonies lysed, the genome normally denatured and then fixed. Alternatively, clinical samples (stool, sputum, pus, etc.) are spotted onto an inert support. The sample is treated in such a way that the DNA is liberated from microbes present in the sample and complexed onto the support. The DNA is normally denatured and fixed in this process. Subsequently, a labelled polynucleotide probe specific for a DNA sequence characteristic of a pathogenic product suspected of being present in the clinical sample is contacted with the fixed genomic single stranded nucleic acid under hybridizing conditions. Hybridization of probes to the single stranded nucleic acid is diagnostic of the presence of the pathogen.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
UNIVERSITY OF WASHINGTONSEATTLE, WA1063

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Falkow, Stanley Portola Valley, CA 15 662
Moseley, Stephen L Kirkland, WA 1 472

Cited Art

Patent Info (Count) # Cites Year
 
DADE BEHRING MARBURG GMBH (1)
4,275,149 Macromolecular environment control in specific receptor assays 397 1978

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
GEN-PROBE INCORPORATED (41)
5,288,611 Method for detecting, identifying, and quantitating organisms and viruses 124 1992
5,364,763 Techniques for preparing specimens for bacterial assays 17 1992
5,639,604 Homogeneous protection assay 34 1993
5,723,597 Ribosomal nucleic acid probes for detecting organisms or groups of organisms 19 1994
5,541,308 Nucleic acid probes for detection and/or quantitation of non-viral organisms 84 1994
7,172,863 Nucleic acid probes and methods for detecting Neisseria gonorrhoeae 1 1994
5,595,874 Nucleic acid probes for detection and/or quantitation of non-viral organisms 29 1994
5,547,842 Nucleic acid probes for detection and/or quantitation of non-viral organisms 36 1994
5,593,841 Nucleic acid probes for detection and/or quantitation of non-viral organisms 10 1994
7,138,516 Oligonucleotide probes for the detection and/or quantitation of non-viral organisms 0 1995
7,090,972 Methods for determining the presence of non-viral organisms in a sample 0 1995
6,150,517 Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms 12 1995
5,994,059 Nucleic acid probes and methods for detecting Streptomyces enterococci 7 1995
5,958,679 Nucleic acid probes and methods for detecting Enterobacter cloacae 6 1995
5,827,651 Nucleic acid probes and methods for detecting fungi 6 1995
5,714,321 Nucleic acid probes and methods for detecting salmonella 18 1995
5,693,468 Nucleic acid probes and methods for detecting chlamydia trachomatis 12 1995
5,693,469 Nucleic acid probes and methods for detecting Escherichia coli 16 1995
5,691,149 Nucleic acid probes and method for detecting Mycoplasma pneumoniae 8 1995
5,683,876 Nucleic acid probes and methods for detecting Proteus mirabilis 7 1995
5,679,520 Nucleic acid probes and methods for detecting eubacteria 12 1995
5,677,127 Nucleic acid probes and methods for detecting group I pseudomonas 10 1995
5,677,128 Nucleic acid probes and methods for detecting mycobacterium 13 1995
5,677,129 Nucleic acid probes and methods for detecting legionella 8 1995
5,674,684 Nucleic acid probes and methods for detecting campylobacters 8 1995
7,087,742 Oligonucleotide probes for the detection and/or quantitation of non-viral organisms 0 1995
5,955,261 Method for detecting the presence of group-specific viral mRNA in a sample 13 1995
5,928,864 Method for determining the presence of organisms in a sample by detecting transfer nucleic acid 15 1995
5,738,988 Method for detecting antimicrobial agents or unknown organisms in a sample using ribosomal probe hybridization 3 1995
5,738,989 Method for determining the sensitivity of microorganisms to anti microbial agents using ribosomal nucleic acid hybridization 2 1995
5,714,324 Methods for producing hybridization probes specific for rRNA subunit subsequences 3 1995
5,688,645 Method for detecting, identifying, and quantitating non-viral organisms 1 1995
5,641,631 Method for detecting, identifying, and quantitating organisms and viruses 15 1995
5,641,632 Method for preparing rRNA for hybridization with a probe 33 1995
5,601,984 Method for detecting, the presense or amount of a taxonomic group of organisms using specific R-RNA subsequences as probes 20 1995
5,567,587 Method for detecting, the presence and amount of prokaryotic organisms using specific rRNA subsequences as probes 52 1995
6,004,745 Hybridization protection assay 21 1995
5,948,899 Compositions for homogenous protection assay 6 1995
5,840,488 Nucleic acid probes for detection and/or quantitation of non-viral organisms 26 1995
6,512,105 Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms 6 2000
7,993,853 Methods of nucleic acid target capture 0 2006
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (30)
4,699,877 Methods and compositions for detecting human tumors 110 1984
4,762,780 Method and composition for screening and diagnosing "HCMV" 37 1987
RE35491 Methods and compositions for detecting human tumors 25 1989
5,447,841 Methods for chromosome-specific staining 171 1990
5,756,696 Compositions for chromosome-specific staining 35 1994
6,872,817 Method of staining target interphase chromosomal DNA 0 1995
6,596,479 Methods and compositions for chromosome-specific staining 6 1995
5,851,767 Detection of prokaryotic organism by DNA hybridization 10 1995
5,721,098 Comparative genomic hybridization 39 1995
5,665,549 Comparative genomic hybridization (CGH) 70 1995
7,115,709 Methods of staining target chromosomal DNA employing high complexity nucleic acid probes 5 1995
6,607,877 Methods and compositions for chromosome-specific staining 8 1995
6,500,612 Methods and compositions for chromosome 21-specific staining 11 1995
6,475,720 Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 6 1995
6,280,929 Method of detecting genetic translocations identified with chromosomal abnormalities 18 1995
6,132,961 Methods of biological dosimetry employing chromosome-specific staining 23 1995
5,976,790 Comparative Genomic Hybridization (CGH) 35 1995
5,965,362 Comparative genomic hybridization (CGH) 29 1995
5,856,097 Comparative genomic hybridization (CGH) 38 1995
6,365,401 Method and probes for the identification of microbial genes specifically induced during host infection 0 1996
6,562,565 Comparative fluorescence hybridization to nucleic acid arrays 12 1996
6,159,685 Comparative genomic hybridization 52 1997
6,548,246 Method and probes for the identification of microbial genes specifically induced during host infection 0 1998
6,335,167 Comparative genomic hybridization (CGH) 33 1999
7,094,534 Detection of chromosoal abnormalities associated with breast cancer 5 2001
7,238,484 Comparative genomic hybridization 2 2004
7,534,567 Detection of nucleic acid sequence differences by comparative genomic hybridization 1 2005
8,021,837 Detection of chromosomal abnormalities associated with breast cancer 0 2006
RE40929 Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 0 2006
7,537,895 Comparative genomic hybridization 0 2006
 
ROCHE MOLECULAR SYSTEMS, INC. (17)
5,176,995 Detection of viruses by amplification and hybridization 107 1989
5,008,182 Detection of AIDS associated virus by polymerase chain reaction 68 1989
5,232,829 Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes 92 1989
5,298,392 Process for detection of water-borne microbial pathogens and indicators of human fecal contamination in water samples and kits therefor 36 1992
5,314,809 Methods for nucleic acid amplification 117 1993
5,712,092 Papillomavirus probe and process for in vitro diagnosis of papillomavirus infections 17 1994
6,040,166 Kits for amplifying and detecting nucleic acid sequences, including a probe 44 1994
6,197,563 Kits for amplifying and detecting nucleic acid sequences 35 1994
5,804,375 Reaction mixtures for detection of target nucleic acids 110 1995
5,604,099 Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids 64 1995
5,876,922 Papillomavirus probe and a process for in vitro diagnosis of papillomavirus infections 19 1995
5,876,723 Purified human papillomavirus type 33 (HPV-33) peptides as an immunogenic composition 7 1997
6,391,539 Immunogenic compositions of human papillomavirus 4 1997
6,107,086 Determined DNA sequences derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions 8 1999
6,242,250 Determined DNA sequences derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions 7 2000
6,514,736 Kits for amplifying and detecting nucleic acid sequences 5 2000
6,827,933 Immunogenic compositions of human papillomavirus and sera produced therefrom 4 2001
 
AMGEN INC. (14)
4,703,008 DNA sequences encoding erythropoietin 276 1984
5,441,868 Production of recombinant erythropoietin 116 1987
4,999,291 Production of human pluripotent granulocyte colony-stimulating factor 86 1989
5,273,882 Method and kit for performing nucleic acid hybridization assays 22 1991
5,955,422 Production of erthropoietin 86 1993
5,580,755 Human pluripotent granulocyte colony-stimulating factor 44 1995
5,756,349 Production of erythropoietin 70 1995
5,621,080 Production of erythropoietin 75 1995
5,618,698 Production of erythropoietin 104 1995
5,547,933 Production of erythropoietin 98 1995
5,676,941 Methods of enhancing bone marrow transplantation and treating burn wounds comprising administering human pluripotent granulocyte colony-stimulating factor 11 1996
5,830,705 Method for recombinant production of human pluripotent granulocyte colony-stimulating factor 17 1996
6,004,548 Analogs of pluripotent granulocyte colony-stimulating factor 14 1998
6,716,606 Production of pluripotent granulocyte colony-stimulating factor 4 2001
 
INSTITUT PASTEUR (13)
4,810,644 Probe and a process for the detection of specific microorganisms, particularly legionellas, in environments which contain them 5 1985
4,992,364 Probe for DNA and a process for the detection of "Shigellae" and entero-invasive strains of Escherichia coli 6 1989
4,963,477 Probe containing a modified nucleic acid, recognizable by specific antibodies and use of this probe and theses specific antibodies to detect and characterize a homologous DNA sequence 22 1989
5,098,825 Probe containing a modified nucleic acid recognizable by specific antibodies and use of this probe to detect and characterize a homologous dna sequence 11 1990
5,817,459 Nucleotide sequences of actinomycetales, oligonucleotides of said sequences and their use for detecting the presence of actinomycetales 0 1991
5,389,513 Method for detecting Listeria monocytogenes 16 1991
5,955,262 Method of detecting and characterizing a nucleic acid or reactant for the application of this method 14 1992
5,492,811 Bacterial diagnostic probe 5 1993
5,876,928 Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method 1 1995
5,605,800 Method of detecting and characterizing a nucleic acid or a sequence of the latter, and enzymatic reactant for the application of this method 3 1995
5,863,721 Bacterial diagnostic probe 1 1995
5,824,795 Oligonucleotides for the detection of salmonella 3 1996
6,017,711 Bacterial diagnostic probe 1 1998
 
LUCA TECHNOLOGIES, INC. (12)
8,092,559 Generation of hydrogen from hydrocarbon bearing materials 0 2005
7,416,879 Thermacetogenium phaeum consortium for the production of materials with enhanced hydrogen content 2 2006
7,426,960 Biogenic fuel gas generation in geologic hydrocarbon deposits 2 2006
7,696,132 Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material 2 2006
7,977,282 Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material 0 2007
8,067,223 consortium for the production of materials with enhanced hydrogen content 0 2008
7,871,792 consortium for the production of materials with enhanced hydrogen content 1 2008
7,845,403 Biogenic fuel gas generation in geologic hydrocarbon deposits 3 2008
7,640,978 Biogenic fuel gas generation in geologic hydrocarbon deposits 4 2008
8,051,908 Biogenic fuel gas generation in geologic hydrocarbon deposits 1 2010
7,975,762 Biogenic fuel gas generation in geologic hydrocarbon deposits 1 2010
8,302,683 Biogenic fuel gas generation in geologic hydrocarbon deposits 0 2011
 
DADE BEHRING MARBURG GMBH (10)
4,994,368 Amplification method for polynucleotide assays 107 1987
5,256,536 Nucleotide probe for Neisseria gonrrhoeae 12 1990
6,294,323 Self initiating single primer amplification of nucleic acids 2 1993
5,525,717 Support-bound nucletide probe for neisseria gonorrhoeae 2 1993
5,679,512 Method for introducing defined sequences at the 3'end of polynucleotides 39 1993
5,397,698 Amplification method for polynucleotide detection assays 24 1993
5,612,199 Method for producing a polynucleotide for use in single primer amplification 23 1994
6,020,461 Hexapeptides of Neisseria gonorrhoeae 0 1995
6,030,774 Method for introducing defined sequences at the 3' end of polynucleotides 21 1995
5,683,879 Methods for producing a single stranded polydeoxynucleotide having two different defined sequences and kits 35 1995
 
ELITECH HOLDING B.V. (10)
6,312,894 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders 32 1998
6,790,945 Fluorescent quenching detection reagents and methods 21 2001
6,653,473 Fluorescent quenching detection reagents and methods 11 2002
6,699,975 Fluorescent quenching detection reagents and methods 13 2002
7,715,989 S) 0 2002
7,751,982 TM leveling methods 0 2003
7,718,374 Single nucleotide polymorphism analysis of highly polymorphic target sequences 0 2008
7,759,126 Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for amplification (or PCR) analysis 0 2008
7,794,945 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders 0 2008
7,897,736 Fluorescent quenching detecting reagents and methods 2 2010
 
MILES INC. (10)
4,542,102 Coupling of nucleic acids to solid support by photochemical methods 121 1983
4,724,202 Use of non-hybridizable nucleic acids for the detection of nucleic acid hybridization 31 1983
4,737,454 Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays 77 1984
4,670,380 Assays utilizing labeled nucleic acid probes 35 1984
4,777,129 Nucleic acid probe detectable by specific nucleic acid binding protein 35 1984
4,743,535 Hybridization assay employing labeled probe and anti-hybrid 50 1984
4,833,084 Monoclonal antibody specific for DNA.RNA hybrids 24 1985
4,959,309 Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays 24 1987
5,200,313 Nucleic acid hybridization assay employing detectable anti-hybrid antibodies 99 1988
5,348,855 Assay for nucleic acid sequences in an unpurified sample 132 1991
 
AMOCO CORPORATION (9)
4,689,295 Test for Salmonella 63 1983
5,639,602 Hybridization assays for the detection of campylobacter 4 1988
5,082,935 Diagnostic reagents made by attaching cytidine containing nucleic acid probes to amino functionalized solid supports by bisulfite mediated transamination 26 1988
5,658,726 Detecting eukaryotic microorganisms 4 1992
5,495,008 Oligonucleotide probes for detection of salmonella 4 1992
5,403,710 Nucleic acid probes and methods for detecting pathogenic candida yeasts 17 1993
5,582,974 Nucleic acid probes for the detection of staphylococcus aureus 4 1993
5,663,049 Detection of campylobacter 1 1995
5,792,854 Detection of salmonella 1 1995
 
CORNELL RESEARCH FOUNDATION, INC. (9)
5,907,085 Grapevine leafroll virus proteins and their uses 8 1996
6,197,948 Grapevine leafroll virus (type 2) proteins and their uses 4 1998
6,093,544 Rupestris stem pitting associated virus nucleic acids, proteins, and their uses 2 1998
6,716,967 Rupestris stem pitting associated virus nucleic acids, proteins, and their uses 0 2000
6,395,490 Detection of Rupestris stem pitting associated virus 0 2000
6,558,953 Grapevine leafroll virus proteins and their uses 2 2000
6,858,426 Grapevine leafroll virus (type 2) proteins and their uses 5 2000
6,638,720 Grapevine leafroll virus proteins and their uses 1 2000
6,916,617 Grapevine leafroll virus proteins and their uses 1 2001
 
INTEGRATED DNA TECHNOLOGIES, INC. (9)
7,476,735 Compounds and methods for labeling oligonucleotides 9 2006
8,084,588 Fluorescence quenching azo dyes, their methods of preparation and use 2 2008
7,605,243 Compounds and methods for labeling oligonucleotides 7 2009
7,645,872 Compounds and methods for labeling oligonucleotides 8 2009
7,803,936 Compounds and methods for labeling oligonucleotides 4 2009
8,114,979 Di-alpha amino anthraquinone compositions 2 2010
8,030,460 Compounds and methods for labeling oligonucleotides 2 2010
8,258,276 Compounds and methods for labeling oligonucleotides 0 2011
8,377,641 Fluorescence quenching azo dyes, their methods of preparation and use 0 2011
 
XDX, INC. (9)
7,026,121 Methods and compositions for diagnosing and monitoring transplant rejection 26 2002
7,235,358 Methods and compositions for diagnosing and monitoring transplant rejection 14 2002
7,691,569 Methods and compositions for diagnosing and monitoring transplant rejection 0 2003
7,645,575 Genes useful for diagnosing and monitoring inflammation related disorders 0 2005
7,993,832 Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders 0 2007
7,829,286 Methods and compositions for diagnosing and monitoring transplant rejection 0 2008
7,785,797 Methods and compositions for diagnosing and monitoring transplant rejection 0 2009
7,960,121 Methods and compositions for diagnosing and monitoring transplant rejection 1 2010
7,879,556 Methods and compositions for diagnosing and monitoring transplant rejection 1 2010
 
YALE UNIVERSITY (7)
4,711,955 Modified nucleotides and methods of preparing and using same 450 1983
4,687,732 Visualization polymers and their application to diagnostic medicine 96 1983
4,888,274 RecA nucleoprotein filament and methods 30 1987
5,328,824 Methods of using labeled nucleotides 189 1987
5,476,928 Modified nucleotides and polynucleotides and complexes form therefrom 112 1992
5,449,767 Modified polynucleotides and methods of preparing same 134 1992
6,203,977 Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization 10 1994
 
CHIRON DIAGNOSTICS CORPORATION (6)
4,775,619 Polynucleotide determination with selectable cleavage sites 165 1984
5,430,136 Oligonucleotides having selectably cleavable and/or abasic sites 54 1990
5,578,717 Nucleotides for introducing selectably cleavable and/or abasic sites into oligonucleotides 52 1995
5,545,730 Multifunctional nucleic acid monomer 59 1995
5,552,538 Oligonucleotides with cleavable sites 51 1995
6,180,339 Nucleic acid probes for the detection and identification of fungi 47 1997
 
DRUG ROYALTY TRUST 9 (6)
6,127,121 Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination 21 1998
6,485,906 Oligonucleotides containing pyrazolo[3,4-d]pyrimidines for hybridization and mismatch discrimination 3 1999
6,492,346 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders 11 2000
7,045,610 Modified oligonucleotides for mismatch discrimination 6 2001
6,683,173 Tm leveling methods 9 2001
7,368,549 T.sub.m leveling compositions 0 2005
 
ESOTERIX GENETIC LABORATORIES, LLC (6)
6,919,174 Methods for disease detection 5 2000
6,964,846 Methods for detecting nucleic acids indicative of cancer 5 2000
6,849,403 Apparatus and method for drug screening 3 2000
7,776,524 Methods for analysis of molecular events 1 2003
7,811,757 Methods for disease detection 0 2006
8,409,829 Methods for analysis of molecular events 0 2010
 
LABORATORY CORPORATION OF AMERICA HOLDINGS (6)
6,905,827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases 59 2002
7,604,936 Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases 0 2003
7,579,148 Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases 0 2004
8,148,067 Methods for diagnosing and monitoring the status of systemic lupus erythematosus 0 2007
7,771,950 Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases 0 2009
8,110,364 Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases 0 2010
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (5)
4,722,891 Methods and compositions for detection of Legionnaires' disease 6 1984
4,745,060 Methods and compositions for the detection of Familial Hypercholesterolemia 7 1984
4,966,837 Methods and compositions for the detection of familial hypercholesterolemia 3 1986
4,857,466 Probe for detection of specific human leukemias 4 1987
5,066,792 Gene probe for detection of specific human leukemias 1 1988
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (5)
4,795,700 Nucleic acid probes and methods of using same 51 1985
5,789,155 Process for identifying nucleic acids and triple helices formed thereby 6 1993
5,874,555 Triple helices and processes for making same 33 1993
6,403,302 Methods and compositions for triple helix formation 1 1993
6,432,638 Triple helix recognition of DNA 17 1998
 
EPOCH BIOSCIENCES, INC. (5)
6,884,584 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders 4 2002
7,205,105 Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis 16 2002
7,348,146 Single nucleotide polymorphism analysis of highly polymorphic target sequences 1 2004
7,485,442 Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis 2 2006
7,556,923 Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders 0 2007
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (5)
5,783,387 Method for identifying and quantifying nucleic acid sequence aberrations 3 1995
6,027,879 Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe 3 1995
5,616,465 Detection and isolation of nucleic acid sequences using competitive hybridization probes 7 1995
5,731,153 Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions 21 1996
6,270,972 Kit for detecting nucleic acid sequences using competitive hybridization probes 0 1999
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (5)
4,675,283 Detection and isolation of homologous, repeated and amplified nucleic acid sequences 26 1984
4,882,268 Method for determining tissue of origin and degree of malignancy of tumor cells 25 1985
4,885,236 Method for determining tissue of origin and presence and extent of cellular abnormalities 26 1986
5,273,877 Non-histological cell type determination 23 1988
RE35747 Method for determining tissue of origin and presence and extent of cellular abnormalities 5 1991
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (5)
5,124,246 Nucleic acid multimers and amplified nucleic acid hybridization assays using same 248 1989
5,594,118 Modified N-4 nucleotides for use in amplified nucleic acid hybridization assays 17 1995
5,795,722 Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample 24 1997
6,265,152 Method and kit for evaluation of HIV mutations 8 1999
6,830,887 Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample 1 2002
 
ABBOTT LABORATORIES (4)
4,960,691 Chromatographic test strip for determining ligands or receptors 135 1986
5,310,650 Method and device for improved reaction kinetics in nucleic acid hybridizations 43 1992
6,100,099 Test strip having a diagonal array of capture spots 21 1998
6,210,898 Method of performing immunochromatography 5 1999
 
APPLIED BIOSYSTEMS, LLC (4)
4,883,750 Detection of specific sequences in nucleic acids 184 1984
5,333,675 Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps 113 1993
5,656,493 System for automated performance of the polymerase chain reaction 145 1994
5,962,223 Detection of specific sequences in nucleic acids 19 1995
 
ENZO DIAGNOSTICS, INC., 40 OAK DRIVE, SYOSSET, NY 11791, A CORP. OF NY (4)
4,894,325 Hybridization method for the detection of genetic material 125 1987
5,384,241 Specific binding assay compound with inhibitive self-quenching characteristics 1 1989
5,241,060 Base moiety-labeled detectable nucleatide 167 1990
5,260,433 Saccharide specific binding system labeled nucleotides 52 1990
 
ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (4)
8,097,405 Nucleic acid sequencing processes using non-radioactive detectable modified or labeled nucleotides or nucleotide analogs, and other processes for nucleic acid detection and chromosomal characterization using such non-radioactive detectable modified or labeled nucleotides or nucleotide analogs 0 1995
7,220,854 Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides 1 1995
7,064,197 System, array and non-porous solid support comprising fixed or immobilized nucleic acids 45 1995
6,992,180 Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides 7 1995
 
IDEXX LABORATORIES, INC. (4)
5,726,010 Reversible flow chromatographic binding assay 93 1991
5,750,333 Reversible flow chromatographic binding assay 44 1995
5,726,013 Reversible flow chromatographic binding assay system, kit, and method 48 1995
6,007,999 Reversible flow chromatographic binding assay 17 1998
 
INTELLIGENT MEDICAL DEVICES, INC. (4)
6,905,816 Clinically intelligent diagnostic devices and methods 39 2001
7,622,250 Clinically intelligent diagnostic devices and methods 0 2005
7,566,533 Clinically intelligent diagnostic devices and methods 1 2006
7,998,679 Devices and methods for diagnosis of susceptibility to diseases and disorders 1 2009
 
LIFE TECHNOLOGIES CORPORATION (4)
7,537,886 Primers and methods for the detection and discrimination of nucleic acids 9 2000
6,830,902 Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis 15 2000
8,043,816 Compositions and methods for temperature-dependent nucleic acid synthesis 0 2009
8,394,609 Primers and methods for the detection and discrimination of nucleic acids 0 2009
 
ORTHO DIAGNOSTIC SYSTEMS INC. (4)
5,324,829 High specific activity nucleic acid probes having target recognition and signal generating moieties 7 1988
5,521,298 High specific activity nucleotide probes having target recognition and signal generation moieties 5 1993
5,486,454 Nucleic acid probe for the detection of Salmonella human pathogens 3 1994
5,783,685 Chemical preparation of high specific activity nucleotide probes 0 1996
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (4)
5,149,624 Method for detecting bacterial or fungal diseases in plants 4 1986
5,830,710 Cloned porphyromonas gingivalis genes and probes for the detection of periodontal disease 8 1994
5,824,791 Cloned porphyromonas gingivalis genes and probes for the detection of periodontal disease 9 1995
8,182,820 Method for inducing cross-reactive immune responses to the human immunodeficiency virus (HIV) in a host by administering feline immunodeficiency virus (FIV) capsid (CA) or reverse transcriptase (RT) immunogens 0 2009
 
CITY OF HOPE (3)
5,075,213 Method for detection and prevention of human cytomegalovirus infection 24 1990
6,242,567 Method for detection and prevention of human cytomegalovirus infection 5 1995
6,133,433 Method for detection and prevention of human cytomegalovirus infection 5 1995
 
EXACT SCIENCES CORPORATION (3)
6,268,136 Methods for stool sample preparation 20 1998
6,551,777 Methods for preserving DNA integrity 16 2000
6,406,857 Methods for stool sample preparation 16 2001
 
GENETICS INSTITUTE, INC. (3)
4,766,062 Displacement polynucleotide assay method and polynucleotide complex reagent therefor 111 1984
4,766,064 Displacement polynucleotide assay employing polyether and diagnostic kit 22 1984
5,268,266 Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences 12 1986
 
HOFFMANN-LA ROCHE INC. (3)
4,617,261 Process for labeling nucleic acids and hybridization probes 50 1985
4,764,460 Recombinant sigma NS protein 4 1985
4,822,731 Process for labeling single-stranded nucleic acids and hybridizaiton probes 27 1986
 
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (3)
5,359,045 Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension 11 1990
5,480,793 Nucleic acid coding for the human angiotensin converting enzyme (ACE), and its uses, especially for the in vitro diagnosis of arterial hypertension 5 1994
5,877,273 Peptides encoded by nuclease sequences of actinomycetales and application as immunogenic compositions 7 1995
 
KREATECH DIAGNOSTICS (3)
5,714,327 Platinum-containing compounds, methods for their preparation and applications thereof 63 1995
5,985,566 Platinum-containing compounds, methods for their preparation and applications thereof 23 1997
6,133,038 Platinum-containing compounds methods for their preparation and applications thereof 4 1998
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (3)
5,514,539 Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines 39 1993
5,763,216 Gene encoding a human reduced folate carrier (RFC) 1 1995
5,716,788 Antibodies to human reduced folate carrier protein 0 1995
 
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (3)
4,480,040 Sensitive and rapid diagnosis of viroid diseases and viruses 56 1981
5,401,630 Species-specific DNA-DNA hybridization probe prepared using chromosome size DNA 1 1991
6,410,223 Direct polymerase chain reaction assay, or bio-PCR 3 1994
 
AMGEN A CORP. OF CALIFORNIA (2)
4,797,355 Methods for attaching polynucleotides to supports 64 1985
4,751,177 Methods and kits for performing nucleic acid hybridization assays 106 1985
 
BATTELLE DEVELOPMENT CORPORATION (2)
4,876,186 Detection and differentiation of coxiella burnetii in biological fluids 1 1985
4,895,795 Detection and differentiation of coxiella burnetii in biological fluids 7 1986
 
BAYER HEALTHCARE LLC (2)
6,007,983 Method and kit for evaluation of HIV mutations 4 1997
6,653,107 Method and kit for evaluation of HIV mutations 0 2001
 
BAYLOR COLLEGE OF MEDICINE (2)
6,156,883 Polyclonal and monoclonal antibodies to Norwalk virus and methods for making them 9 1993
6,942,865 Methods and reagents to detect and characterize norwalk and related viruses 2 2002
 
BIOSEPARATIONS, INC. (2)
5,948,617 Methods of in situ hybridization 0 1997
6,194,146 Situ and in vitro hybridization method and buffer 1 1997
 
BIOSITE INCORPORATED (2)
5,480,792 Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays 27 1993
5,679,526 Threshold ligand-receptor assay 23 1994
 
BOEHRINGER MANNHEIM GMBH (2)
4,834,918 Process and reagent for increasing the quantum yield in chemiluminescent reactions 3 1986
5,741,637 Process for the production of modified nucleic acids 3 1994
 
DIAGNOSTICS FOR THE REAL WORLD, LTD. (2)
7,186,508 Capture and detection of target nucleic acid in dipstick assays 3 2001
7,867,706 Capture and detection of target nucleic acid in dipstick assays 0 2007
 
E. I. DU PONT DE NEMOURS AND COMPANY (2)
4,670,379 Polynucleotide hydridization assays employing catalyzed luminescence 17 1984
4,831,125 DNA probe for corynebacterium kutscheri 4 1985
 
GENENTECH, INC. (2)
5,049,488 Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase 7 1985
5,169,762 Human nerve growth factor by recombinant technology 24 1988
 
ICOS CORPORATION (2)
6,599,727 Human poly (ADP-ribose) polymerase 2 materials and methods 0 2000
6,989,260 Human poly(ADP-ribose) polymerase 2 materials and methods 0 2003
 
ISIS PHARMACEUTICALS, INC. (2)
5,837,449 Compositions and methods for modulating .beta.-amyloid 9 1994
6,177,246 Compositions and methods for modulating .beta.-amyloid 7 1998
 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (2)
7,368,233 Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm 5 2000
7,981,612 Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm 0 2008
 
MILES LABORATORIES, INC. (2)
4,689,294 Enhancement of hybridization of nucleic acids by anionic polymers 15 1984
4,563,417 Nucleic acid hybridization assay employing antibodies to intercalation complexes 100 1984
 
MOLECULAR DIAGNOSTICS, INC. (2)
4,748,111 Nucleic acid-protein conjugate used in immunoassay 32 1984
4,692,509 Radioactive labeling of proteins with nucleosides or nucleotides 4 1984
 
OMNIGENE,INC., (2)
4,866,167 Detection of human oral cells by nucleic acid hybridization 7 1985
4,925,785 Nucleic acid hybridization assays 114 1986
 
OREGON HEALTH & SCIENCE UNIVERSITY (2)
5,026,837 DNA probe which reveals a hypervariable region on human chromosome 16 1 1987
5,077,400 DNA probe which reveals a hypervariable region on human chromosome 17 1 1988
 
PFIZER INC. (2)
6,280,974 Recombinant feline coronavirus S proteins 3 1995
6,642,359 Recombinant feline coronavirus S proteins 1 2001
 
PRINCETON UNIVERSITY (2)
4,882,269 Amplified hybridization assay 65 1986
5,424,188 Amplified hybridization assay 37 1992
 
PURINA MILLS, INC. (2)
6,297,027 Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof 1 1996
6,277,592 Porcine leptin protein, nucleic acid sequences coding therefor and uses thereof 1 1996
 
SANGTEC MEDICAL AB (2)
4,486,539 Detection of microbial nucleic acids by a one-step sandwich hybridization test 120 1982
4,563,419 Detection of microbial nucleic acids by a one-step sandwich hybridization test 208 1983
 
SCHERING CORPORATION (2)
5,001,230 T cell activation markers 31 1988
5,136,022 T cell activation markers 1 1991
 
SCIENCE & TECHNOLOGY CORPORATION @ UNM (2)
5,750,340 In situ hybridization solution and process 15 1995
6,022,689 Situ hybridization slide processes 6 1996
 
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (2)
4,677,054 Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization 120 1983
4,720,454 Genetic probe used in the detection of adrenal hyperplasia 9 1984
 
THE TEXAS A&M UNIVERSITY SYSTEM (2)
5,310,649 Method for detecting species and biovars of Brucella 2 1990
5,348,857 Probes and method for identifying species and biovars of brucella 0 1992
 
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (2)
5,660,983 Maize cytoplasmic male sterility type T (cms-T) mitochondria DNA 0 1994
7,101,989 DsrA protein and polynucleotides encoding the same 0 2000
 
UNIVERSITY OF WASHINGTON (2)
7,138,259 PDEs and uses thereof 1 2001
7,598,067 PDEs and uses thereof 0 2006
 
WAKE FOREST UNIVERSITY HEALTH SCIENCES (2)
7,579,147 Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease 0 2003
8,192,928 Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease 0 2009
 
ABERLYN CAPITAL MANAGEMENT LIMITED PARTNERSHIP (1)
4,704,355 Assay utilizing ATP encapsulated within liposome particles 26 1985
 
ADVANCED MAGNETICS, INC. (1)
4,672,040 Magnetic particles for use in separations 181 1985
 
AKZO NOBEL N.V. (1)
5,474,895 Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor 118 1993
 
ALBERT EINSTEIN COLLEGE OF MEDICINE (1)
4,562,159 Diagnostic test for hepatitis B virus 28 1981
 
ALLIED SIGNAL (1)
4,767,699 Diagnostic reagent, kit and method employing polynucleotide displacement, separation, enzymatic cleavage and adenosine phosphate detection 28 1985
 
AMEN INC. (1)
6,379,661 Pharmaceutical compositions comprising pluripotent granulocyte colony-stimulating factor 9 1999
 
AMERSHAM INTERNATIONAL PLC (1)
4,656,127 Method of detecting mutations in DNA and RNA 140 1984
 
ARCH DEVELOPMENT CORPORATION (1)
5,712,372 Human thyroid hormone receptor 5 1995
 
ASTRA AKTIEBOLAG (1)
5,250,411 Nucleic acid probes specific for Plasmodium vivax and methods of using the same 2 1990
 
BATTELLE MEMORIAL INSTITUTE (1)
5,258,283 Detection and differentiation of coxiella burnetii in biological fluids 2 1989
 
BIOGEN, INC. (1)
5,004,689 DNA sequences, recombinant DNA molecules and processes for producing human gamma interferon-like polypeptides in high yields 17 1987
 
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (1)
4,581,331 Method for the rapid detection of virus and viral antigens 5 1983
 
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (1)
5,370,998 Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis 6 1991
 
BODYSYNC, INC. (1)
7,054,758 Computer-assisted means for assessing lifestyle risk factors 29 2001
 
CALIMETRICS, INC. (1)
6,344,314 Determined DNA sequenced derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions 6 2001
 
CANBERRA INDUSTRIES, INC. (1)
5,108,893 Use of oxidase enzyme systems in chemiluminescent assays 12 1990
 
CELERA CORPORATION (1)
6,103,465 Methods and reagents for typing HLA class I genes 5 1995
 
CHIRON BEHRING GMBH & CO. (1)
5,550,223 Lipoprotein I (ompi) of pseudomonas aeruginosa 2 1994
 
CHIRON CORPORATION (1)
4,623,627 Monoclonal antibody having specificity for the double-stranded conformation of native DNA and diagnostic methods using same 19 1983
 
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (1)
5,693,500 Diagnosis of Mycobacterium bovis infection 2 1995
 
DADE BEHRING INC. (1)
5,043,267 Method for rapid detection of bacterial and fungal infection 4 1990
 
DIAGNOSTIC RESEARCH LIMITED PARTNERSHIP (1)
4,652,517 Methods for the in vitro detection and identification of unknown pathogens or genetic entities 40 1984
 
DIGENE PARTNERS LIMITED PARTNERSHIP (1)
4,820,630 Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels 102 1984
 
EMORY UNIVERSITY (1)
5,296,349 Molecular genetic test for myoclonic epilepsy 5 1990
 
ENERGY, UNITED STATES DEPARTMENT OF (1)
6,548,251 Inhibition of molecular and biological processes using modified oligonucleotides 0 2000
 
ENZO BIOCHEM, INC. (1)
4,987,065 In vivo labelling of polynucleotide sequences 60 1985
 
ENZO LIFE SCIENCES, INC. (1)
4,994,373 Method and structures employing chemically-labelled polynucleotide probes 279 1989
 
ENZO THERAPEUTICS, INC. (1)
7,713,528 Method for in vivo delivery of active compounds using reagent conjugate 0 1995
 
EPOCH PHARMACEUTICALS, INC. (1)
6,949,367 Modified oligonucleotides for mismatch discrimination 9 2000
 
EXPRESSION DIAGNOSTICS, INC. (1)
7,892,745 Methods and compositions for diagnosing and monitoring transplant rejection 0 2009
 
EXXONMOBIL UPSTREAM RESEARCH COMPANY (1)
6,543,535 Process for stimulating microbial activity in a hydrocarbon-bearing, subterranean formation 45 2001
 
GENE-TRAK SYSTEMS (1)
5,089,386 Test for listeria 43 1987
 
GENERAL ELECTRIC COMPANY (1)
8,158,405 Process for concentrating and processing fluid samples 0 2008
 
GENETICS, INC. (1)
4,588,682 Binding nucleic acid to a support 31 1982
 
GENZYME CORPORATION (1)
4,626,501 Labeled DNA 24 1983
 
GEORGETOWN UNIVERSITY (1)
5,057,411 Type-specific papillomavirus DNA sequences and peptides 45 1989
 
GOLDMAN SACHS BANK USA (1)
5,932,416 Method for detecting the presence of RNA belonging to an organ or tissue cell-type 1 1995
 
HAHNEMANN UNIVERSITY A PA NON-PROFIT CORP (1)
4,483,920 Immobilization of message RNA directly from cells onto filter material 106 1982
 
HEALTH RESEARCH, INC. (1)
5,070,011 DNA probes for the detection of Haemophilus Ducreyi and method of use 2 1989
 
HYBRITECH INCORPORATED (1)
4,727,019 Method and apparatus for immunoassays 114 1985
 
ID BIOMEDICAL CORPORATION (1)
5,660,988 Cycling probe cleavage detection of nucleic acid sequences 125 1995
 
IMREG, INC. (1)
4,490,472 Sensitive tests for malignancies based on DNA detection 12 1982
 
INCYTE PHARMACEUTICALS, INC. (1)
6,183,968 Composition for the detection of genes encoding receptors and proteins associated with cell proliferation 14 1999
 
INSTITUT NATIONAL DE LA SANTE (1)
5,411,857 Probes for papillomaviruses and an in vitro diagnostic procedure for papilloma infections 26 1992
 
INTEGRATED GENETICS, INC. (1)
4,785,086 Test for Campylobacter 14 1985
 
INTERNATIONAL GENETIC ENGINEERING, INC. (1)
5,242,823 Cloning of the 38kd Mycoplasma hyorhinis regression-associated antigen 4 1992
 
JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (1)
5,514,550 Nucleic acid test article and its use to detect a predetermined nucleic acid 28 1994
 
KIRIN-AMGEN, INC. (1)
4,810,643 Production of pluripotent granulocyte colony-stimulating factor 180 1986
 
LIFE TECHNOLOGIES, INC. (1)
4,446,237 Method for detection of a suspect viral deoxyribonucleic acid in an acellular biological fluid 24 1981
 
LOCKHEED MARTIN CORPORATION (1)
5,162,199 Neisseria-specific DNA probe 10 1990
 
LORUS THERAPEUTICS INC. (1)
7,223,849 Oligonucleotides from the untranslated regions of housekeeping genes and methods of using same to modulate cell growth 0 1997
 
MCCANN & ASSOCIATES INC (1)
5,494,797 Method for detecting lyme disease 3 1994
 
MEDIEL ESTABLISHMENT (1)
6,420,182 Prenatal gender prediction test 0 1999
 
MOLECULAR BIOSYSTEMS, INC. (1)
5,541,313 Single-stranded labelled oligonucleotides of preselected sequence 74 1994
 
MUREX DIAGNOSTICS CORPORATION (1)
5,501,949 Particle bound binding component immunoassay 32 1994
 
NEN LIFE SCIENCE PRODUCTS, INC. (1)
5,726,012 Rapid, high capacity nucleic acid based assay 3 1994
 
NEW YORK UNIVERSITY (1)
4,533,628 Colony hybridization method 6 1983
 
NORDISK INSULINLABORATORIUM NIELS STEENSENSVEJ 1 (1)
4,623,619 Method for the determination of liability in human individuals to develop atherosclerosis 16 1983
 
NORVAL B. GALLOWAY (1)
5,521,300 Oligonucleotides complementary to mycobacterial nucleic acids 25 1991
 
NOVARTIS;CORPORATE INTELLECTUAL PROPERTY (1)
5,486,452 Devices and kits for immunological analysis 117 1987
 
OLIN CORPORATION (1)
5,004,682 Method and kit for detecting live microorganisms in chlorine- or bromine-treated water 9 1987
 
ONCOR, INC. (1)
5,451,502 Restriction amplification assay 6 1993
 
ORGENICS LTD. (1)
5,221,609 Molecular genetic probe, and method of forming same, assay technique and kit using said molecular genetic probe 0 1991
 
OSAKA UNIVERSITY (1)
5,486,473 A DNA coding for a Flavivirus antigen 2 1994
 
PACKARD BIOSCIENCE COMPANY (1)
4,933,276 Use of oxidase enzyme systems in chemiluminescent assays 14 1987
 
PARAMOUNT CAPITAL, INC. (1)
4,587,044 Linkage of proteins to nucleic acids 93 1983
 
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (1)
4,542,096 Detecting rearranged human c-myc DNA fragments associated with oncogenes 6 1983
 
PROFIGEN, INC. (1)
6,399,308 Rupestris stem pitting associated virus nucleic acids, proteins, and their uses 0 2000
 
RODLAN, KARIN D. (1)
4,908,307 Hybridization method and probe for detecting nucleic acid sequences 40 1986
 
ROYAL FREE HOSPITAL SCHOOL OF MEDICINE (1)
4,937,199 Detection of viruses and antibodies 4 1987
 
SHIMADZU CORPORATION (1)
5,043,264 DNA probes for detecting salmonella and a method for detecting salmonella therewith 2 1989
 
SIMON, LIONEL (1)
6,028,188 Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages 13 1994
 
SMITHKLINE BECKMAN CORPORATION (1)
4,840,892 Polynucleotide hybridization probes 11 1985
 
STANDARD OIL COMPANY (INDIANA) (1)
5,049,489 16S rRNA oligonucleotide probes for the identification of sulfate-reducing bacteria 5 1989
 
STICHTING KLINISCHE RESEARCH ACADEMISCH MEDISCH CENTRUM (1)
5,580,990 Pt-containing compound, process for its preparation, and application of such compounds 28 1993
 
SYMBICOM AKTIEBOLAG (1)
6,610,838 P13 antigens from Borrelia 1 1998
 
SYNGENE, INC. (1)
5,668,266 Synthesis of single-stranded labelled oligonucleotides of preselected sequence 12 1995
 
TEPNEL LIFECODES CORPORATION (1)
5,593,832 Method for forensic analysis 1 1995
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
5,629,414 Diagnostic genes for toxoplasmosis 3 1994
 
THE GENERAL HOSPITAL CORPORATION (1)
5,534,406 Method of detecting antigenic nucleic acid-containing macromolecular entities 11 1994
 
THE JOHNS HOPKINS UNIVERSITY (1)
6,177,251 Method for detection of target nucleic acid by analysis of stool 21 1999
 
THE ROCKEFELLER UNIVERSITY (1)
4,801,530 Nucleotide hybridization assay for protozoan parasites 15 1987
 
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (1)
4,537,718 Impermeant spectroscopic probes 1 1982
 
TM BIOSCIENCE CORPORATION (1)
5,770,365 Nucleic acid capture moieties 37 1995
 
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (1)
4,792,519 Method for the monitoring and control of microbial populations 3 1985
 
UNIVERSITY OF UTAH (1)
5,645,994 Method and compositions for identification of species in a sample using type II topoisomerase sequences 24 1995
 
UNIVERSITY OF VIRGINIA (1)
5,124,252 In vitro test for fecal leukocytes 9 1989
 
VYSIS, INC. (1)
6,268,128 Immobilized oligonucleotide probes and uses thereof 43 1992
 
WASHINGTON RESEARCH FOUNDATION (1)
5,770,714 Chlamydia major outer membrane protein 22 1995
 
WISCONSIN ALUMNI RESEARCH FOUNDATION (1)
4,918,178 Test for Johne's disease 9 1987
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (12)
4,717,653 Method for identifying and characterizing organisms 77 1981
4,647,529 Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide 45 1984
4,774,176 Sensitive tests for malignancies based on DNA detection 1 1984
5,348,854 Method for detecting prokaryotic organisms 37 1987
4,851,330 Method for detection, identification and quantitation of non-viral organisms 148 1987
5,132,206 Fluorescent pigments for tagging biological molecules 12 1988
5,087,558 Method for identifying and characterizing organisms 73 1989
5,030,556 Species-specific DNNA probe for the detection of Branhamella catarrhalis 10 1989
5,047,320 Method for detection and prevention of human cytomegalovirus infection 1990
5,075,215 Use of daylight fluorescent pigments for tagging biological molecules 9 1991
5,354,657 Process for the highly specific detection of nucleic acids in solid 11 1992
5,614,361 Method for identifying and characterizing organisms 3 1994