Maytansinoids
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United States of America Patent
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-
Dec 21, 1982
Grant Date -
N/A
app pub date -
Sep 17, 1980
filing date -
Sep 21, 1979
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Antibiotic C-15003 PHO of the formula: ##STR1## wherein R.sub.1 is H, hydroxyl, alkanoyloxy, alkenylcarbonyloxy or arylcarbonyloxy; R.sub.2 is H, hydroxyl or alkanoyloxy; R.sub.3 is H or alkanoyloxy is produced by introducing a hydroxyl group into 15-position of a maytansinoid compound, and, if desired, thus obtained compound is subjected to deacylation or acylation. Antibiotic C-15003 PHO is useful as antiprotozoal or antitumor agent.
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