Chemical compounds
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United States of America Patent
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Dec 21, 1982
Issued Date -
N/A
app pub date -
Apr 30, 1981
filing date -
Apr 20, 1972
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
An antiinflammatory steroid exhibiting a tendency to crystal growth in suspension in aerosol propellants is contacted with a halogenated hydrocarbon to form a crystalline solvate, which, after removal of some or all of the propellant from the crystals, is reduced to a particle size permitting inhalation into the human bronchial system when dispersed as an aerosol, the micronised crystalline solvate not thereafter exhibiting crystal growth in the aerosol propellant. The solvate is a new composition of matter which has been characterized by I.R. spectra and the aerosol formulation prepared therefrom has valuable therapeutic properties, particularly in the treatment of asthma.
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