2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives
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United States of America Patent
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Jan 18, 1983
Grant Date -
N/A
app pub date -
Jul 17, 1981
filing date -
Jul 17, 1981
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Herein are disclosed compounds of the formula ##STR1## in which R.sup.1 is hydrogen, lower alkyl or --(CH.sub.2).sub.m --NR.sup.4 R.sup.5 wherein m is an integer from 2 to 6 and R.sup.4 and R.sup.5 each is hydrogen or lower alkyl; R.sup.2 is hydrogen, bromo or chloro; and R.sup.3 is hydrogen or halo; with the requirement that when R.sup.2 is bromo or chloro, then R.sup.3 is bromo or chloro or a therapeutically acceptable salt thereof. The compounds inhibit lens aldose reductase in a diabetic mammal.
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