Enzyme-resistant opiate pentapeptides

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United States of America Patent

PATENT NO 4371463
SERIAL NO

05769686

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Abstract

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Pentapeptides having the formula H-L-Tyr-A-Gly-L-Phe-B-R wherein A is a D-amino acid residue, Sar or L-Pro, B is L-Met of L-Leu, and R is NH.sub.2 or OH. These pentapeptides are synthetic analogues of the naturally-occurring Met-and Leu-enkephalins and possess opiate activity which is resistant to destruction by body enzymes.

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Patent Owner(s)

  • NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Jaw-Kang Pulerton, CA 16 180
Pert, Candace B Bethesda, MD 10 129

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