Synthesis of acylated benzothiophenes

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United States of America Patent

PATENT NO 4380635
SERIAL NO

06331046

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Abstract

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A group of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)benzoyl]benzo[b]thiophenes are prepared by acylation of a methyl-protected starting compound followed by demethylation in a single reaction mixture.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ELI LILLY AND COMPANYINDIANAPOLIS, IN869

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Peters, Mary K Indianapolis, IN 1 265

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (6)
6268361 Naphthyl compounds, intermediates, compositions, and methods 4 1995
* 2002/0132,816 Estrogen agonists/antagonists for preventing breast cancer 1 2002
* 2005/0239,840 Benzothiophenes, formulations containing same, and methods 0 2005
8501690 Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue 8 2010
* 2010/0317,712 Estrogen Agonists/Antagonists For Preventing Breast Cancer 0 2010
8933028 Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue 0 2013
 
ICEUTICA PTY LTD. (6)
9095496 Formulation of indomethacin 0 2014
8992982 Formulation of indomethacin 0 2014
9089471 Formulation of indomethacin 1 2014
9526734 Formulation of meloxicam 0 2015
9522135 Formulation of indomethacin 0 2015
9649318 Formulation of meloxicam 0 2015
 
WYETH (1)
* 5827876 Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo?b!-thiophenes 8 1997
 
ELAN PHARMA INTERNATIONAL LIMITED (2)
* 2006/0159,628 Nanoparticulate benzothiophene formulations 1 2005
* 2009/0035,366 Nanoparticulate benzothiophene formulations 10 2008
 
PFIZER PRODUCTS INC. (2)
* 6204286 Estrogen agonists/antagonists 22 1997
* 6153622 Estrogen agonists/antagonists 23 1998
 
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (1)
* 5470854 2-phenylbenzo[B]furans, process for their manufacture and pharmaceutical preparations containing them 69 1994
 
Effik SCA BAT (1)
* 6165491 Pharmaceutical composition based on estrogen and progesterone 27 1998
 
BOSTON SCIENTIFIC SCIMED, INC. (6)
6491938 Therapeutic inhibitor of vascular smooth muscle cells 115 2001
8067022 Therapeutic inhibitor of vascular smooth muscle cells 0 2001
6569441 Therapeutic inhibitor of vascular smooth muscle cells 109 2001
7625410 Stent device and method 0 2006
8158670 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
8097642 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
 
TOYOTA JIDOSHA KABUSHIKI KAISHA (1)
* 5852193 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals 2 1998
 
BAYLOR UNIVERSITY (1)
* 5886025 Anti-mitotic agents which inhibit tubulin polymerization 17 1997
 
PFIZER INC. (5)
* 5589482 Benzo-thiophene estrogen agonists to treat prostatic hyperplasia 6 1994
6441193 Estrogen agonists/antagonists 10 1999
6911456 Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions 2 2002
RE39558 5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis 1 2004
* 2005/0148,625 Use of estrogen antagonists and estrogen agonists inhibiting pathological conditions 0 2005
 
PONIARD PHARMACEUTICALS, INC. (15)
* 5847007 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 21 1994
* 5770609 Prevention and treatment of cardiovascular pathologies 102 1995
* 5595722 Method for identifying an agent which increases TGF-beta levels 85 1995
* 6166090 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 2 1997
* 5945456 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 36 1997
6197789 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues 32 1997
* 6117911 Compounds and therapies for the prevention of vascular and non-vascular pathologies 92 1998
6251920 Prevention and treatment of cardiovascular pathologies 16 1998
6262079 Prevention and treatment of cardiovascular pathologies 29 1999
6410587 Compounds and therapies for the prevention of vascular and non-vascular pathologies 34 2000
* 2006/0135,560 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues 0 2003
7084171 Compounds and therapies for the prevention of vascular and non-vascular pathologies 15 2004
* 2005/0020,667 Compounds and therapies for the prevention of vascular and non-vascular pathologies 1 2004
7511070 Compounds and therapies for the prevention of vascular and non-vascular pathologies 5 2005
* 2006/0084,696 Compounds and therapies for the prevention of vascular and non-vascular pathologies 5 2005
 
ELI LILLY AND COMPANY (227)
* 5482950 Methods for lowering serum cholesterol 16 1993
* 5461065 Methods for inhibiting endometriosis 26 1993
* 5457113 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 98 1993
* 5457116 Methods of inhibiting uterine fibrosis 32 1993
* 5441964 Methods for inhibiting bone loss using substituted benzothiophene 37 1993
* 5418252 Method for inhibiting cartilage degradation 28 1993
* 5391557 Methods for the treatment of peri-menopausal syndrome 44 1993
* 5480904 Methods for inhibiting uterine fibrosis 17 1993
6489355 Methods of inhibiting the effects of amyloidogenic proteins 0 1993
6417198 Methods of inhibiting CNS problems in post-menopausal women 0 1993
* 5708009 Methods of inhibiting myeloperoxidase activity 2 1993
* 5672610 Methods of increasing macrophage function 2 1993
* 5596004 Methods of inhibiting male infertility 0 1993
* 5593987 Methods of inhibiting breast disorders 5 1993
* 5578613 Methods for inhibiting weight gain or inducing weight loss 7 1993
* 5574047 Methods of inhibiting imperfect tissue repair 14 1993
* 5574048 Methods of inhibiting hirsutism and alopecia in women 3 1993
* 5552415 Method of inhibiting Alzheimer's Disease 34 1993
* 5534526 Methods for inhibiting vasomotor symptoms and attending psychological disturbances surrounding post-menopausal syndrome 13 1993
* 5521198 Methods of inhibiting autoimmune diseases 19 1993
* 5492927 Non-peptide tachykinin receptor antagonists to treat allergy 37 1993
* 5476862 Methods of increasing thrombomodulin expression 7 1993
* 5462949 Methods of inhibiting fertility in women 24 1993
* 5462950 Methods of treating menstrual symptoms and compositions therefore 33 1993
* 5461064 Methods of inhibiting atrophy of the skin and vagina 25 1993
* 5451589 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 20 1993
* 5451590 Methods of inhibiting sexual precocity 20 1993
* 5447941 Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes 30 1993
* 5446053 Methods of inhibiting dysfunctional uterine bleeding 28 1993
* 5441965 Methods of inhibiting thrombin 32 1993
* 5441966 Methods of inhibiting Turner's syndrome 24 1993
* 5439923 Method of inhibiting seborrhea and acne 27 1993
* 5439931 Method for increasing libido in post-menopausal women 27 1993
* 5389670 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder 39 1993
* 5591753 Combination treatment for osteoporosis 13 1994
* 5478847 Methods of use for inhibiting bone loss and lowering serum cholesterol 29 1994
* 5604248 Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs 5 1994
* 5466810 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes 23 1994
* 5420349 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[.beta.]thiophenes 1 1994
* 5550123 Methods for inhibiting bone prosthesis degeneration 3 1994
* 5550151 Methods of reducing scarring in wound healing 0 1994
* 5512296 Methods for inhibiting neuronal damage 7 1994
* 5502074 Benzothiophenes for bone healing and fracture repair 5 1994
* 5496828 Methods of inhibiting ulcerative mucositis 25 1994
* 5494920 Methods of inhibiting viral replication 10 1994
* 5434166 Methods of inhibiting demyelinating and desmyelinating diseases 27 1994
* 5550150 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder 6 1994
* 5731436 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 1 1994
* 5631369 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 2 1994
* 5629425 Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene 19 1994
7501441 Naphthyl compounds, intermediates, processes, compositions, and methods 0 1994
6703407 Benzofuran compounds, compositions, and methods 1 1994
* 5658931 Method for inhibiting mammalian breast carcinoma with tamoxifen, and analogs thereof, and certain naphthyl compounds 14 1994
* 5554628 Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs 3 1994
* 5843964 Methods of inhibiting endometrial mitoses 10 1994
6562862 Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y 0 1994
* 5545641 Methods of inhibiting physiological conditions associated with an excess of bradykinin 4 1994
* 5494929 Methods of inhibiting growth hormone effects 6 1995
* 5521214 Methods of inhibiting environmental estrogens 6 1995
* 5512583 Methods of decreasing serum calcium levels 0 1995
6479517 Phosphorous-containing benzothiophenes 2 1995
* 5998401 Naphthyl compounds, intermediates, compositions, and methods 6 1995
6653328 3-benzyl-benzothiophenes 0 1995
6395755 Benzothiophene pharmaceutical compounds 2 1995
6391892 Naphthyl pharmaceutical compounds 3 1995
6384053 .alpha.-substituted-1-benzyl-napthyls 2 1995
* 5622974 .alpha.-substituted-3-benzyl-benzofurans 16 1995
* 5523309 Benzofuran pharmaceutical compounds 38 1995
* 5532382 Benzothiophenes substituted at the 3-carbonyl 24 1995
* 5514703 Benzothiophene compounds useful for inhibiting lipoxygenase 10 1995
* 5514704 Benzothiophenes to inhibit leukotrienes 8 1995
* 5686467 Methods of inhibiting imperfect tissue repair 12 1995
* 5686468 Methods of inhibiting hirsutism and alopecia in women 4 1995
* 5686476 Methods of inhibiting Alzheimer's Disease 24 1995
* 5578614 Methods for inhibiting weight gain or inducing weight loss 5 1995
* 5554755 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes 2 1995
* 5525624 Non-peptide tachykinin receptor antagonists to treat psycological disorder 22 1995
* 5610166 Methods for inhibiting angiogenesis 17 1995
* 5614639 Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof 1 1995
* 5693656 Methods for inhibiting endometriosis 4 1995
* 5688812 Method of inhibiting seborrhea and acne 5 1995
* 5688813 Methods of inhibiting thrombin 12 1995
* 5641790 Methods of use for inhibiting bone loss and lowering serum cholesterol 25 1995
* 5610168 Methods of use for inhibiting bone loss and lowering serum cholesterol 13 1995
* 5552416 Methods of inhibiting dysfunctional uterine bleeding 3 1995
* 5508292 Methods of inhibiting thrombin 22 1995
* 5496851 Methods of inhibiting cell-cell adhesion 18 1995
* 5492926 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 21 1995
* 5462937 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 32 1995
6399634 Benzothiophene compounds, compositions, and methods 2 1995
* 5492921 Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation 11 1995
6608090 Benzothiophenes with novel basic side chains 2 1995
6437137 Naphthyl compounds, intermediates, processes, compositions, and methods 0 1995
6410564 Naphthyl compounds, intermediates, processes, compositions, and methods 4 1995
* 5484795 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis 40 1995
* 5484796 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation 14 1995
* 5484797 Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis 18 1995
* 5663184 Methods of inhibiting CNS problems in post-menopausal women 3 1995
6407243 Benzofuran compounds, compositions, and methods 5 1995
* 5770612 Methods of treating menstrual symptoms and compositions there for 2 1995
* 5760061 Methods of treating menstrual symptoms and compositions therefore 4 1995
* 5843962 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 3 1995
* 5760060 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 1 1995
* 5719165 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 0 1995
* 5552417 Methods of Inhibiting sexual precocity 3 1995
* 5708010 Methods of inhibiting myeloperoxidase activity 3 1995
6436958 Methods of inhibiting autoimmune diseases 0 1995
* 5610167 Methods of inhibiting atrophy of the skin and vagina 3 1995
* 5698572 Methods of inhibiting turner's syndrome 2 1995
* 5622975 Methods for inhibiting vascular smooth muscle cell migration 27 1995
6472531 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 1 1995
6399778 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 0 1995
* 5843974 Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se 5 1995
* 5731327 Synthesis of 3-?4-(2-aminoethoxy)benzoyl!-2-aryl-6-hydroxybenzo ?b!thiophenes 12 1995
* 5599822 Methods for minimizing bone loss 8 1995
* 5574190 Naphthyl compounds, intermediates, compositions, and methods 14 1995
* 5567712 Naphthyl compounds, intermediates, compositions and methods 6 1995
6545027 Methods of modulating NF-kB transcription factor 0 1995
6444688 Compounds and compositions with nitrogen-containing non-basic side chains 2 1995
6372945 Process for the synthesis of vinyl sulfoxides 0 1995
* 5606075 Process for the synthesis of benzo[b]thiophenes 3 1995
* 5606076 Process for the synthesis of benzo[b]thiophenes 2 1995
* 5596106 Cannabinoid receptor antagonists 55 1995
* 5569772 Process for the synthesis of benzo[b]thiophenes 2 1995
* 5567828 Compounds and compositions with nitrogen-containing non-basic side 25 1995
* 5532254 Modulation of calcium channels using benzothiophenes 11 1995
* 5514826 Vinyl sulfenic acid derivatives 3 1995
* 5512701 Process for the synthesis of vinyl sulfenic acid derivatives 2 1995
* 5624940 Aqueous solution inclusion complexes of benzothiophene compounds with water soluble cyclodextrins, and pharmaceutical formulations and methods thereof 9 1995
* 5808061 Intermediates and processes for preparing benzothiophene compounds 2 1995
* 5512684 Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophenes 3 1995
* 5556876 Methods for lowering serum cholesterol 5 1995
* 5552433 Method for lowering serum cholesterol 8 1995
* 5521172 Methods for lowering serum cholesterol 7 1995
* 5700815 Methods of increasing thrombomodulin expression 5 1995
* 5576337 Method of treating anxiety by inhibiting physiological conditions associated with an excess of neuropeptide Y 13 1995
* 5567714 Methods of treating obesity by inhibiting physiological conditions associated with an excess of neuropeptide Y 22 1995
* 5567715 Methods of treating depression by inhibiting physiological conditions associated with an excess of neuropeptide Y 2 1995
* 5504094 Use of bengothiophenls to treat pain due to an excess of neuropeptide y 16 1995
6274601 Methods of inhibiting ulcerative mucositis 2 1995
6451817 Alpha-substituted-1-benzyl-napthyls 0 1995
6417199 3-benzyl-benzothiophenes 2 1995
* 5705507 Aplha-substituted-3-benzyl-benzofurans 2 1995
* 5712390 Process for preparing 2-substituted benzo ?B! Thiophene compounds and intermediates thereof 0 1995
* 5710285 Process for preparing 2-substituted benzo?B!thiophene compounds and intermediates thereof 3 1995
* 5691353 Method of inhibiting aortal smooth muscle cell proliferation using naphthyl compounds 4 1995
* 5750688 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 1 1996
* 5652259 Methods of inhibiting Alzheimer's disease 11 1996
6440958 Acrylic and propionic acid compounds, intermediates, processes, compositions, and methods 2 1996
* 6124311 Methods for treating resistant tumors 8 1996
* 6121292 Methods for reversing multidrug resistance 1 1996
* 5631247 Compounds and compositions with nitrogen-containing non-basic side chains 3 1996
* 5811421 Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods 4 1996
* 5646137 Combination treatment for osteoporosis 20 1996
* 5792870 2-amino-3-aroyl-benzo?.beta.!thiophenes and methods for preparing and using same to produce 6-hdyroxy-2-(4-hydroxyphenyl)-3-?4-(2-aminoethoxy)-benzoyl!benzo?.beta.!thiophenes 1 1996
* 5691355 Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs 14 1996
* 5747524 Cannabinoid receptor antagonists 50 1996
6432982 Benzothiophenes, and formulations and methods using same 2 1997
* 5747510 Pharmaceutical unit dosage formulations 20 1997
* 5731342 Benzothiophenes, formulations containing same, and methods 15 1997
* 5688796 Heterocyclic substituted benzothiophenes, compositions, and methods 5 1997
* 6110942 Method for minimizing the uterotrophic effect of droloxifene 0 1997
6432983 Benzothiophene compounds intermediates processes and methods of use 4 1997
* 5760030 Benzothiophene compounds and methods of use 6 1997
6713494 Amorphous benzothiophenes, methods of preparation and methods of use 10 1997
6599920 Naphthalene compounds, intermediates, formulations, and methods 2 1997
* 5958916 Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods 7 1997
6593345 Naphthyl compounds, intermediates, compositions, and methods of use 2 1997
* 5998442 Benzo [B] thiophene compounds, and compositions for treating bone loss, and hyperlipidemia 2 1997
* 5843965 Benzo ?B! thiophene compounds, intermediates, processes, compositions, and methods 3 1997
* 6017914 Benzo[b]thiophene compounds, intermediates, formulations, and methods 2 1997
* 5948796 Benzo?B!thiophene compounds, intermediates, formulations, and methods 2 1997
* 5929090 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods 5 1997
* 5856341 Benzo ?B! indeno ?2,1-D! thiophene compounds, intermediates, processes, compositions and methods 4 1997
* 5843963 Benzothiophene compounds, intermediates, processes, compositions, and methods 2 1997
* 5834488 Dihydrobenzo ?B! indeno ?2, 1-D! thiophene compounds, intermediates, processes, compositions and methods 2 1997
* 5792762 Dihydrobenzofluorene compounds, intermediates, compositions and methods 1 1997
* 5981570 Benzothiophene compounds, compositions, and methods 2 1997
* 5977383 Process for the synthesis of benzothiophenes 1 1997
* 5889000 Naphthofluorene compounds, intermediates, compositions and methods 0 1997
* 5958917 Benzofluorene compounds, intermediates, compositions, and methods 1 1997
* 5821253 Tetrahydrobenzo?a!fluorene compounds and methods of use 0 1997
* 5916916 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods 11 1997
6350884 Acrylic and propionic acid compounds, intermediates, processes, compositions, and method 1 1997
* 5998443 Phosphorous containing benzothiophenes for treating estrogen deficiency 0 1997
* 5985897 Benzothiphene compounds, intermediates, compositions, and methods 3 1997
* 5952350 Naphthyl compounds and compositions, as estrogen receptor binding agents 4 1997
* 5843940 Benzothiophene compounds, compositions, and method 3 1997
* 5969157 Process for the synthesis of benzothiophenes 6 1997
* 5955608 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 0 1998
* 6025373 Methods for reducing fibrinogen 0 1998
* 5994370 Indene compounds having activity as SERMS 0 1998
* 6090949 Processes for preparing benzothiophenes 0 1998
* 6043360 Intermediates and a process for preparing benzo[B]thiophenes 0 1998
* 6025495 Regioselective alkylation process for preparing substituted benzo[b]thiophenes 0 1998
* 6018056 Intermediates and processes for preparing benzo (b) thiophenes 1 1998
* 5994547 Process for preparing benzo[b]thiophenes 1 1998
* 6121293 Benzothiophene compounds, compositions, and methods 3 1998
* 5977098 Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods 1 1998
* 5977382 Benzo[b]thiophene compounds, intermediates, processes, compositions, and methods 0 1998
* 5952513 Benzo?b! thiophene compounds 1 1998
* 6075146 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals 1 1998
* 6020513 Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods 0 1998
6509356 1-(4-(Substituted alkoxy)benzyl)naphthalene compounds having estrogen inhibitory activity 5 1998
* 6103740 Methods for lowering platelet counts 4 1998
* 6090843 Benzothiophenes compounds which have useful pharmaceutical activity 4 1998
* 6008232 Methods for preventing headaches 3 1998
* 5908859 Benzothiophenes for inhibiting hyperlipidemia 5 1998
* 6008377 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes 1 1998
* 6075151 Benzothiophene compounds, intermediates, processes, compositions, and methods 5 1998
* 5990129 Methods for regulating trkA expression 6 1998
* 6060488 Benzothiophenes for treating estrogen deficiency 6 1998
6403614 Benzothiophenes 0 1998
* 6133458 Benzo[B]indeno[2, 1-D]thiophene compounds, intermediates, compositions, and methods 2 1998
* 5959103 Naphthofluorene compounds, intermediates, compositions, and methods 0 1998
6353003 Method for reducing levels of homocysteine and C-reactive protein 5 1999
6355632 Naphthyl compounds, intermediates, compositions, and methods 1 2000
6921827 Process for preparing 3-aryl-benzo{b} thiophenes 0 2001
RE39049 Methods for inhibiting bone loss 7 2003
* RE39050 Methods of use for inhibiting bone loss and lowering serum cholesterol 6 2003
RE38968 Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride 8 2003
6906086 Methods for inhibiting bone loss 4 2003
7012153 Process for preparing benzoic acids 1 2003
6894064 Benzothiophenes, formulations containing same, and methods 12 2004
7105541 Naphthyl compounds, intermediates, compositions, and methods of use 0 2004
* 2006/0106,010 Methods for inhibiting bone loss 0 2005
8030330 Benzothiophenes, formulations containing same, and methods 0 2010
 
CIPLA LIMITED (1)
8344149 Crystalline form of benzothiophene compound and process for preparation thereof 0 2007
* Cited By Examiner