US Patent No: 4,380,635

Number of patents in Portfolio can not be more than 2000

Synthesis of acylated benzothiophenes

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Abstract

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A group of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)benzoyl]benzo[b]thiophenes are prepared by acylation of a methyl-protected starting compound followed by demethylation in a single reaction mixture.

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Patent Owner(s)

  • ELI LILLY AND COMPANY

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Peters, Mary K Indianapolis, IN 1 262

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (271)
* 5,482,950 Methods for lowering serum cholesterol 16 1993
* 5,461,065 Methods for inhibiting endometriosis 26 1993
* 5,457,113 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 97 1993
* 5,457,116 Methods of inhibiting uterine fibrosis 32 1993
* 5,441,964 Methods for inhibiting bone loss using substituted benzothiophene 37 1993
* 5,418,252 Method for inhibiting cartilage degradation 28 1993
* 5,391,557 Methods for the treatment of peri-menopausal syndrome 44 1993
* 5,480,904 Methods for inhibiting uterine fibrosis 17 1993
6,489,355 Methods of inhibiting the effects of amyloidogenic proteins 0 1993
6,417,198 Methods of inhibiting CNS problems in post-menopausal women 0 1993
* 5,708,009 Methods of inhibiting myeloperoxidase activity 2 1993
* 5,672,610 Methods of increasing macrophage function 2 1993
* 5,596,004 Methods of inhibiting male infertility 0 1993
* 5,593,987 Methods of inhibiting breast disorders 5 1993
* 5,578,613 Methods for inhibiting weight gain or inducing weight loss 6 1993
* 5,574,047 Methods of inhibiting imperfect tissue repair 14 1993
* 5,574,048 Methods of inhibiting hirsutism and alopecia in women 3 1993
* 5,552,415 Method of inhibiting Alzheimer's Disease 34 1993
* 5,534,526 Methods for inhibiting vasomotor symptoms and attending psychological disturbances surrounding post-menopausal syndrome 13 1993
* 5,521,198 Methods of inhibiting autoimmune diseases 19 1993
* 5,492,927 Non-peptide tachykinin receptor antagonists to treat allergy 37 1993
* 5,476,862 Methods of increasing thrombomodulin expression 7 1993
* 5,462,949 Methods of inhibiting fertility in women 24 1993
* 5,462,950 Methods of treating menstrual symptoms and compositions therefore 33 1993
* 5,461,064 Methods of inhibiting atrophy of the skin and vagina 24 1993
* 5,451,589 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 20 1993
* 5,451,590 Methods of inhibiting sexual precocity 20 1993
* 5,447,941 Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes 29 1993
* 5,446,053 Methods of inhibiting dysfunctional uterine bleeding 28 1993
* 5,441,965 Methods of inhibiting thrombin 32 1993
* 5,441,966 Methods of inhibiting Turner's syndrome 24 1993
* 5,439,923 Method of inhibiting seborrhea and acne 27 1993
* 5,439,931 Method for increasing libido in post-menopausal women 27 1993
* 5,389,670 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder 39 1993
* 5,591,753 Combination treatment for osteoporosis 13 1994
* 5,478,847 Methods of use for inhibiting bone loss and lowering serum cholesterol 29 1994
* 5,470,854 2-phenylbenzo[B]furans, process for their manufacture and pharmaceutical preparations containing them 68 1994
* 5,604,248 Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs 5 1994
* 5,847,007 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 21 1994
* 5,466,810 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes 23 1994
* 5,420,349 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[.beta.]thiophenes 1 1994
* 5,550,123 Methods for inhibiting bone prosthesis degeneration 3 1994
* 5,550,151 Methods of reducing scarring in wound healing 0 1994
* 5,512,296 Methods for inhibiting neuronal damage 7 1994
* 5,502,074 Benzothiophenes for bone healing and fracture repair 5 1994
* 5,496,828 Methods of inhibiting ulcerative mucositis 25 1994
* 5,494,920 Methods of inhibiting viral replication 9 1994
* 5,434,166 Methods of inhibiting demyelinating and desmyelinating diseases 27 1994
* 5,550,150 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder 6 1994
* 5,731,436 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 1 1994
* 5,631,369 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 2 1994
* 5,629,425 Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene 19 1994
7,501,441 Naphthyl compounds, intermediates, processes, compositions, and methods 0 1994
6,703,407 Benzofuran compounds, compositions, and methods 1 1994
* 5,658,931 Method for inhibiting mammalian breast carcinoma with tamoxifen, and analogs thereof, and certain naphthyl compounds 14 1994
* 5,554,628 Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs 3 1994
* 5,843,964 Methods of inhibiting endometrial mitoses 9 1994
6,562,862 Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y 0 1994
* 5,545,641 Methods of inhibiting physiological conditions associated with an excess of bradykinin 4 1994
* 5,589,482 Benzo-thiophene estrogen agonists to treat prostatic hyperplasia 6 1994
* 5,494,929 Methods of inhibiting growth hormone effects 6 1995
* 5,521,214 Methods of inhibiting environmental estrogens 6 1995
* 5,512,583 Methods of decreasing serum calcium levels 0 1995
6,479,517 Phosphorous-containing benzothiophenes 2 1995
* 5,998,401 Naphthyl compounds, intermediates, compositions, and methods 6 1995
6,653,328 3-benzyl-benzothiophenes 0 1995
6,395,755 Benzothiophene pharmaceutical compounds 2 1995
6,391,892 Naphthyl pharmaceutical compounds 3 1995
6,384,053 .alpha.-substituted-1-benzyl-napthyls 2 1995
* 5,622,974 .alpha.-substituted-3-benzyl-benzofurans 16 1995
* 5,523,309 Benzofuran pharmaceutical compounds 38 1995
* 5,532,382 Benzothiophenes substituted at the 3-carbonyl 24 1995
* 5,514,703 Benzothiophene compounds useful for inhibiting lipoxygenase 10 1995
* 5,514,704 Benzothiophenes to inhibit leukotrienes 8 1995
* 5,686,467 Methods of inhibiting imperfect tissue repair 12 1995
* 5,686,468 Methods of inhibiting hirsutism and alopecia in women 3 1995
* 5,686,476 Methods of inhibiting Alzheimer's Disease 24 1995
* 5,578,614 Methods for inhibiting weight gain or inducing weight loss 5 1995
* 5,554,755 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes 2 1995
* 5,525,624 Non-peptide tachykinin receptor antagonists to treat psycological disorder 22 1995
* 5,610,166 Methods for inhibiting angiogenesis 17 1995
* 5,614,639 Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof 1 1995
* 5,693,656 Methods for inhibiting endometriosis 4 1995
* 5,688,812 Method of inhibiting seborrhea and acne 5 1995
* 5,688,813 Methods of inhibiting thrombin 12 1995
* 5,641,790 Methods of use for inhibiting bone loss and lowering serum cholesterol 25 1995
* 5,610,168 Methods of use for inhibiting bone loss and lowering serum cholesterol 13 1995
* 5,552,416 Methods of inhibiting dysfunctional uterine bleeding 3 1995
* 5,508,292 Methods of inhibiting thrombin 22 1995
* 5,496,851 Methods of inhibiting cell-cell adhesion 18 1995
* 5,492,926 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 20 1995
* 5,462,937 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 32 1995
6,399,634 Benzothiophene compounds, compositions, and methods 2 1995
* 5,492,921 Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation 11 1995
6,608,090 Benzothiophenes with novel basic side chains 2 1995
6,437,137 Naphthyl compounds, intermediates, processes, compositions, and methods 0 1995
6,410,564 Naphthyl compounds, intermediates, processes, compositions, and methods 4 1995
* 5,484,795 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis 40 1995
* 5,484,796 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation 14 1995
* 5,484,797 Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis 18 1995
* 5,663,184 Methods of inhibiting CNS problems in post-menopausal women 3 1995
6,407,243 Benzofuran compounds, compositions, and methods 5 1995
* 5,770,612 Methods of treating menstrual symptoms and compositions there for 2 1995
* 5,760,061 Methods of treating menstrual symptoms and compositions therefore 4 1995
* 5,843,962 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 3 1995
* 5,760,060 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 1 1995
* 5,719,165 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 0 1995
* 5,552,417 Methods of Inhibiting sexual precocity 3 1995
* 5,708,010 Methods of inhibiting myeloperoxidase activity 3 1995
6,436,958 Methods of inhibiting autoimmune diseases 0 1995
* 5,610,167 Methods of inhibiting atrophy of the skin and vagina 2 1995
* 5,698,572 Methods of inhibiting turner's syndrome 2 1995
* 5,622,975 Methods for inhibiting vascular smooth muscle cell migration 27 1995
6,472,531 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 1 1995
6,399,778 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 0 1995
6,268,361 Naphthyl compounds, intermediates, compositions, and methods 4 1995
* 5,843,974 Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se 5 1995
* 5,731,327 Synthesis of 3-?4-(2-aminoethoxy)benzoyl!-2-aryl-6-hydroxybenzo ?b!thiophenes 12 1995
* 5,599,822 Methods for minimizing bone loss 8 1995
* 5,574,190 Naphthyl compounds, intermediates, compositions, and methods 14 1995
* 5,567,712 Naphthyl compounds, intermediates, compositions and methods 6 1995
6,545,027 Methods of modulating NF-kB transcription factor 0 1995
6,444,688 Compounds and compositions with nitrogen-containing non-basic side chains 2 1995
6,372,945 Process for the synthesis of vinyl sulfoxides 0 1995
* 5,770,609 Prevention and treatment of cardiovascular pathologies 99 1995
* 5,606,075 Process for the synthesis of benzo[b]thiophenes 3 1995
* 5,606,076 Process for the synthesis of benzo[b]thiophenes 2 1995
* 5,595,722 Method for identifying an agent which increases TGF-beta levels 85 1995
* 5,596,106 Cannabinoid receptor antagonists 53 1995
* 5,569,772 Process for the synthesis of benzo[b]thiophenes 2 1995
* 5,567,828 Compounds and compositions with nitrogen-containing non-basic side 25 1995
* 5,532,254 Modulation of calcium channels using benzothiophenes 11 1995
* 5,514,826 Vinyl sulfenic acid derivatives 3 1995
* 5,512,701 Process for the synthesis of vinyl sulfenic acid derivatives 2 1995
* 5,624,940 Aqueous solution inclusion complexes of benzothiophene compounds with water soluble cyclodextrins, and pharmaceutical formulations and methods thereof 9 1995
* 5,808,061 Intermediates and processes for preparing benzothiophene compounds 2 1995
* 5,512,684 Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophenes 3 1995
* 5,556,876 Methods for lowering serum cholesterol 5 1995
* 5,552,433 Method for lowering serum cholesterol 8 1995
* 5,521,172 Methods for lowering serum cholesterol 7 1995
* 5,700,815 Methods of increasing thrombomodulin expression 5 1995
* 5,576,337 Method of treating anxiety by inhibiting physiological conditions associated with an excess of neuropeptide Y 13 1995
* 5,567,714 Methods of treating obesity by inhibiting physiological conditions associated with an excess of neuropeptide Y 21 1995
* 5,567,715 Methods of treating depression by inhibiting physiological conditions associated with an excess of neuropeptide Y 2 1995
* 5,504,094 Use of bengothiophenls to treat pain due to an excess of neuropeptide y 16 1995
6,274,601 Methods of inhibiting ulcerative mucositis 2 1995
6,451,817 Alpha-substituted-1-benzyl-napthyls 0 1995
6,417,199 3-benzyl-benzothiophenes 2 1995
* 5,705,507 Aplha-substituted-3-benzyl-benzofurans 2 1995
* 5,712,390 Process for preparing 2-substituted benzo ?B! Thiophene compounds and intermediates thereof 0 1995
* 5,710,285 Process for preparing 2-substituted benzo?B!thiophene compounds and intermediates thereof 3 1995
* 5,691,353 Method of inhibiting aortal smooth muscle cell proliferation using naphthyl compounds 4 1995
* 5,750,688 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 1 1996
* 5,652,259 Methods of inhibiting Alzheimer's disease 11 1996
6,440,958 Acrylic and propionic acid compounds, intermediates, processes, compositions, and methods 2 1996
* 6,124,311 Methods for treating resistant tumors 8 1996
* 6,121,292 Methods for reversing multidrug resistance 1 1996
* 5,631,247 Compounds and compositions with nitrogen-containing non-basic side chains 3 1996
* 5,811,421 Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods 4 1996
* 5,646,137 Combination treatment for osteoporosis 20 1996
* 5,792,870 2-amino-3-aroyl-benzo?.beta.!thiophenes and methods for preparing and using same to produce 6-hdyroxy-2-(4-hydroxyphenyl)-3-?4-(2-aminoethoxy)-benzoyl!benzo?.beta.!thiophenes 1 1996
* 5,691,355 Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs 14 1996
* 5,747,524 Cannabinoid receptor antagonists 48 1996
6,432,982 Benzothiophenes, and formulations and methods using same 2 1997
* 5,747,510 Pharmaceutical unit dosage formulations 20 1997
* 5,731,342 Benzothiophenes, formulations containing same, and methods 14 1997
* 5,688,796 Heterocyclic substituted benzothiophenes, compositions, and methods 5 1997
* 5,886,025 Anti-mitotic agents which inhibit tubulin polymerization 17 1997
* 5,827,876 Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo?b!-thiophenes 8 1997
* 6,110,942 Method for minimizing the uterotrophic effect of droloxifene 0 1997
6,432,983 Benzothiophene compounds intermediates processes and methods of use 3 1997
* 6,204,286 Estrogen agonists/antagonists 22 1997
* 5,760,030 Benzothiophene compounds and methods of use 5 1997
6,713,494 Amorphous benzothiophenes, methods of preparation and methods of use 7 1997
6,599,920 Naphthalene compounds, intermediates, formulations, and methods 2 1997
* 5,958,916 Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods 7 1997
6,593,345 Naphthyl compounds, intermediates, compositions, and methods of use 2 1997
* 5,998,442 Benzo [B] thiophene compounds, and compositions for treating bone loss, and hyperlipidemia 2 1997
* 5,843,965 Benzo ?B! thiophene compounds, intermediates, processes, compositions, and methods 3 1997
* 6,017,914 Benzo[b]thiophene compounds, intermediates, formulations, and methods 2 1997
* 5,948,796 Benzo?B!thiophene compounds, intermediates, formulations, and methods 2 1997
* 5,929,090 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods 5 1997
* 5,856,341 Benzo ?B! indeno ?2,1-D! thiophene compounds, intermediates, processes, compositions and methods 4 1997
* 5,843,963 Benzothiophene compounds, intermediates, processes, compositions, and methods 2 1997
* 5,834,488 Dihydrobenzo ?B! indeno ?2, 1-D! thiophene compounds, intermediates, processes, compositions and methods 2 1997
* 5,792,762 Dihydrobenzofluorene compounds, intermediates, compositions and methods 1 1997
* 5,981,570 Benzothiophene compounds, compositions, and methods 2 1997
* 5,977,383 Process for the synthesis of benzothiophenes 1 1997
* 5,889,000 Naphthofluorene compounds, intermediates, compositions and methods 0 1997
* 5,958,917 Benzofluorene compounds, intermediates, compositions, and methods 1 1997
* 5,821,253 Tetrahydrobenzo?a!fluorene compounds and methods of use 0 1997
* 5,916,916 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods 11 1997
6,350,884 Acrylic and propionic acid compounds, intermediates, processes, compositions, and method 1 1997
* 5,998,443 Phosphorous containing benzothiophenes for treating estrogen deficiency 0 1997
* 5,985,897 Benzothiphene compounds, intermediates, compositions, and methods 3 1997
* 5,952,350 Naphthyl compounds and compositions, as estrogen receptor binding agents 4 1997
* 5,843,940 Benzothiophene compounds, compositions, and method 3 1997
* 6,166,090 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 2 1997
* 5,945,456 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 36 1997
* 5,969,157 Process for the synthesis of benzothiophenes 5 1997
6,197,789 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues 29 1997
* 5,955,608 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 0 1998
* 6,025,373 Methods for reducing fibrinogen 0 1998
* 6,117,911 Compounds and therapies for the prevention of vascular and non-vascular pathologies 84 1998
* 5,994,370 Indene compounds having activity as SERMS 0 1998
* 6,090,949 Processes for preparing benzothiophenes 0 1998
* 6,043,360 Intermediates and a process for preparing benzo[B]thiophenes 0 1998
* 6,025,495 Regioselective alkylation process for preparing substituted benzo[b]thiophenes 0 1998
* 6,018,056 Intermediates and processes for preparing benzo (b) thiophenes 1 1998
* 5,994,547 Process for preparing benzo[b]thiophenes 0 1998
* 5,852,193 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals 2 1998
6,251,920 Prevention and treatment of cardiovascular pathologies 15 1998
* 6,121,293 Benzothiophene compounds, compositions, and methods 3 1998
* 5,977,098 Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods 1 1998
* 5,977,382 Benzo[b]thiophene compounds, intermediates, processes, compositions, and methods 0 1998
* 5,952,513 Benzo?b! thiophene compounds 1 1998
* 6,075,146 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals 1 1998
* 6,020,513 Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods 0 1998
* 6,165,491 Pharmaceutical composition based on estrogen and progesterone 26 1998
6,509,356 1-(4-(Substituted alkoxy)benzyl)naphthalene compounds having estrogen inhibitory activity 5 1998
* 6,103,740 Methods for lowering platelet counts 4 1998
* 6,090,843 Benzothiophenes compounds which have useful pharmaceutical activity 4 1998
* 6,008,232 Methods for preventing headaches 3 1998
* 5,908,859 Benzothiophenes for inhibiting hyperlipidemia 5 1998
* 6,008,377 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes 1 1998
* 6,075,151 Benzothiophene compounds, intermediates, processes, compositions, and methods 5 1998
* 6,153,622 Estrogen agonists/antagonists 23 1998
* 5,990,129 Methods for regulating trkA expression 4 1998
* 6,060,488 Benzothiophenes for treating estrogen deficiency 6 1998
6,403,614 Benzothiophenes 0 1998
* 6,133,458 Benzo[B]indeno[2, 1-D]thiophene compounds, intermediates, compositions, and methods 2 1998
* 5,959,103 Naphthofluorene compounds, intermediates, compositions, and methods 0 1998
6,353,003 Method for reducing levels of homocysteine and C-reactive protein 5 1999
6,262,079 Prevention and treatment of cardiovascular pathologies 26 1999
6,441,193 Estrogen agonists/antagonists 10 1999
6,355,632 Naphthyl compounds, intermediates, compositions, and methods 1 2000
6,410,587 Compounds and therapies for the prevention of vascular and non-vascular pathologies 28 2000
6,491,938 Therapeutic inhibitor of vascular smooth muscle cells 107 2001
8,067,022 Therapeutic inhibitor of vascular smooth muscle cells 0 2001
6,921,827 Process for preparing 3-aryl-benzo{b} thiophenes 0 2001
6,569,441 Therapeutic inhibitor of vascular smooth muscle cells 97 2001
6,911,456 Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions 2 2002
* 2002/0132,816 Estrogen agonists/antagonists for preventing breast cancer 1 2002
RE39049 Methods for inhibiting bone loss 7 2003
* RE39050 Methods of use for inhibiting bone loss and lowering serum cholesterol 6 2003
RE38968 Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride 8 2003
6,906,086 Methods for inhibiting bone loss 4 2003
* 2006/0135,560 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues 0 2003
7,012,153 Process for preparing benzoic acids 1 2003
6,894,064 Benzothiophenes, formulations containing same, and methods 9 2004
7,084,171 Compounds and therapies for the prevention of vascular and non-vascular pathologies 14 2004
* 2005/0020,667 Compounds and therapies for the prevention of vascular and non-vascular pathologies 0 2004
7,105,541 Naphthyl compounds, intermediates, compositions, and methods of use 0 2004
RE39558 5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis 1 2004
* 2005/0148,625 Use of estrogen antagonists and estrogen agonists inhibiting pathological conditions 0 2005
* 2005/0239,840 Benzothiophenes, formulations containing same, and methods 0 2005
* 2006/0106,010 Methods for inhibiting bone loss 0 2005
7,511,070 Compounds and therapies for the prevention of vascular and non-vascular pathologies 4 2005
* 2006/0084,696 Compounds and therapies for the prevention of vascular and non-vascular pathologies 4 2005
* 2006/0159,628 Nanoparticulate benzothiophene formulations 1 2005
7,625,410 Stent device and method 0 2006
8,158,670 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
8,097,642 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
8,344,149 Crystalline form of benzothiophene compound and process for preparation thereof 0 2007
* 2009/0035,366 Nanoparticulate benzothiophene formulations 9 2008
8,030,330 Benzothiophenes, formulations containing same, and methods 0 2010
8,501,690 Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue 6 2010
8,933,028 Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue 0 2013
9,095,496 Formulation of indomethacin 0 2014
8,992,982 Formulation of indomethacin 0 2014
9,089,471 Formulation of indomethacin 0 2014
* Cited By Examiner