US Patent No: 4,380,635

Number of patents in Portfolio can not be more than 2000

Synthesis of acylated benzothiophenes

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Abstract

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A group of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)benzoyl]benzo[b]thiophenes are prepared by acylation of a methyl-protected starting compound followed by demethylation in a single reaction mixture.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ELI LILLY AND COMPANYINDIANAPOLIS, IN874

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Peters, Mary K Indianapolis, IN 1 258

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Patent Info (Count) # Cites Year
 
Eli Lilly and Company (226)
* 5,482,950 Methods for lowering serum cholesterol 16 1993
* 5,461,065 Methods for inhibiting endometriosis 26 1993
* 5,457,113 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 93 1993
* 5,457,116 Methods of inhibiting uterine fibrosis 32 1993
* 5,441,964 Methods for inhibiting bone loss using substituted benzothiophene 37 1993
* 5,418,252 Method for inhibiting cartilage degradation 28 1993
* 5,391,557 Methods for the treatment of peri-menopausal syndrome 44 1993
* 5,480,904 Methods for inhibiting uterine fibrosis 17 1993
6,489,355 Methods of inhibiting the effects of amyloidogenic proteins 0 1993
6,417,198 Methods of inhibiting CNS problems in post-menopausal women 0 1993
* 5,708,009 Methods of inhibiting myeloperoxidase activity 2 1993
* 5,672,610 Methods of increasing macrophage function 2 1993
* 5,596,004 Methods of inhibiting male infertility 0 1993
* 5,593,987 Methods of inhibiting breast disorders 5 1993
* 5,578,613 Methods for inhibiting weight gain or inducing weight loss 6 1993
* 5,574,047 Methods of inhibiting imperfect tissue repair 14 1993
* 5,574,048 Methods of inhibiting hirsutism and alopecia in women 3 1993
* 5,552,415 Method of inhibiting Alzheimer's Disease 31 1993
* 5,534,526 Methods for inhibiting vasomotor symptoms and attending psychological disturbances surrounding post-menopausal syndrome 12 1993
* 5,521,198 Methods of inhibiting autoimmune diseases 19 1993
* 5,492,927 Non-peptide tachykinin receptor antagonists to treat allergy 37 1993
* 5,476,862 Methods of increasing thrombomodulin expression 7 1993
* 5,462,949 Methods of inhibiting fertility in women 24 1993
* 5,462,950 Methods of treating menstrual symptoms and compositions therefore 33 1993
* 5,461,064 Methods of inhibiting atrophy of the skin and vagina 24 1993
* 5,451,589 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 20 1993
* 5,451,590 Methods of inhibiting sexual precocity 20 1993
* 5,447,941 Methods of inhibiting pulmonary hypertensive diseases with raloxifene and related benzothiophenes 29 1993
* 5,446,053 Methods of inhibiting dysfunctional uterine bleeding 28 1993
* 5,441,965 Methods of inhibiting thrombin 32 1993
* 5,441,966 Methods of inhibiting Turner's syndrome 24 1993
* 5,439,923 Method of inhibiting seborrhea and acne 26 1993
* 5,439,931 Method for increasing libido in post-menopausal women 27 1993
* 5,389,670 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder 39 1993
* 5,591,753 Combination treatment for osteoporosis 13 1994
* 5,478,847 Methods of use for inhibiting bone loss and lowering serum cholesterol 28 1994
* 5,604,248 Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs 5 1994
* 5,466,810 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes 23 1994
* 5,420,349 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[.beta.]thiophenes 1 1994
* 5,550,123 Methods for inhibiting bone prosthesis degeneration 3 1994
* 5,550,151 Methods of reducing scarring in wound healing 0 1994
* 5,512,296 Methods for inhibiting neuronal damage 7 1994
* 5,502,074 Benzothiophenes for bone healing and fracture repair 5 1994
* 5,496,828 Methods of inhibiting ulcerative mucositis 25 1994
* 5,494,920 Methods of inhibiting viral replication 9 1994
* 5,434,166 Methods of inhibiting demyelinating and desmyelinating diseases 26 1994
* 5,550,150 Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder 6 1994
* 5,731,436 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 1 1994
* 5,631,369 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 2 1994
* 5,629,425 Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene 19 1994
7,501,441 Naphthyl compounds, intermediates, processes, compositions, and methods 0 1994
6,703,407 Benzofuran compounds, compositions, and methods 1 1994
* 5,658,931 Method for inhibiting mammalian breast carcinoma with tamoxifen, and analogs thereof, and certain naphthyl compounds 11 1994
* 5,554,628 Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs 2 1994
* 5,843,964 Methods of inhibiting endometrial mitoses 3 1994
6,562,862 Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y 0 1994
* 5,545,641 Methods of inhibiting physiological conditions associated with an excess of bradykinin 4 1994
* 5,494,929 Methods of inhibiting growth hormone effects 6 1995
* 5,521,214 Methods of inhibiting environmental estrogens 6 1995
* 5,512,583 Methods of decreasing serum calcium levels 0 1995
6,479,517 Phosphorous-containing benzothiophenes 2 1995
* 5,998,401 Naphthyl compounds, intermediates, compositions, and methods 6 1995
6,653,328 3-benzyl-benzothiophenes 0 1995
6,395,755 Benzothiophene pharmaceutical compounds 2 1995
6,391,892 Naphthyl pharmaceutical compounds 3 1995
6,384,053 .alpha.-substituted-1-benzyl-napthyls 2 1995
* 5,622,974 .alpha.-substituted-3-benzyl-benzofurans 16 1995
* 5,523,309 Benzofuran pharmaceutical compounds 38 1995
* 5,532,382 Benzothiophenes substituted at the 3-carbonyl 24 1995
* 5,514,703 Benzothiophene compounds useful for inhibiting lipoxygenase 10 1995
* 5,514,704 Benzothiophenes to inhibit leukotrienes 8 1995
* 5,686,467 Methods of inhibiting imperfect tissue repair 12 1995
* 5,686,468 Methods of inhibiting hirsutism and alopecia in women 3 1995
* 5,686,476 Methods of inhibiting Alzheimer's Disease 24 1995
* 5,578,614 Methods for inhibiting weight gain or inducing weight loss 5 1995
* 5,554,755 2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.]thiophenes 2 1995
* 5,525,624 Non-peptide tachykinin receptor antagonists to treat psycological disorder 22 1995
* 5,610,166 Methods for inhibiting angiogenesis 17 1995
* 5,614,639 Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof 1 1995
* 5,693,656 Methods for inhibiting endometriosis 4 1995
* 5,688,812 Method of inhibiting seborrhea and acne 5 1995
* 5,688,813 Methods of inhibiting thrombin 12 1995
* 5,641,790 Methods of use for inhibiting bone loss and lowering serum cholesterol 25 1995
* 5,610,168 Methods of use for inhibiting bone loss and lowering serum cholesterol 13 1995
* 5,552,416 Methods of inhibiting dysfunctional uterine bleeding 3 1995
* 5,508,292 Methods of inhibiting thrombin 22 1995
* 5,496,851 Methods of inhibiting cell-cell adhesion 18 1995
* 5,492,926 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 20 1995
* 5,462,937 Methods for inhibiting vascular smooth muscle cell proliferation and restinosis 32 1995
6,399,634 Benzothiophene compounds, compositions, and methods 2 1995
* 5,492,921 Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation 11 1995
6,608,090 Benzothiophenes with novel basic side chains 2 1995
6,437,137 Naphthyl compounds, intermediates, processes, compositions, and methods 0 1995
6,410,564 Naphthyl compounds, intermediates, processes, compositions, and methods 4 1995
* 5,484,795 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis 40 1995
* 5,484,796 Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting aortal smooth muscle cell proliferation 14 1995
* 5,484,797 Naphthly compounds, intermediates, processes, compositions, and method for inhibiting endometrosis 18 1995
* 5,663,184 Methods of inhibiting CNS problems in post-menopausal women 3 1995
6,407,243 Benzofuran compounds, compositions, and methods 5 1995
* 5,770,612 Methods of treating menstrual symptoms and compositions there for 2 1995
* 5,760,061 Methods of treating menstrual symptoms and compositions therefore 4 1995
* 5,843,962 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 3 1995
* 5,760,060 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 1 1995
* 5,719,165 Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism 0 1995
* 5,552,417 Methods of Inhibiting sexual precocity 3 1995
* 5,708,010 Methods of inhibiting myeloperoxidase activity 3 1995
6,436,958 Methods of inhibiting autoimmune diseases 0 1995
* 5,610,167 Methods of inhibiting atrophy of the skin and vagina 2 1995
* 5,698,572 Methods of inhibiting turner's syndrome 2 1995
* 5,622,975 Methods for inhibiting vascular smooth muscle cell migration 27 1995
6,472,531 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 1 1995
6,399,778 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 0 1995
* 5,843,974 Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se 5 1995
* 5,731,327 Synthesis of 3-?4-(2-aminoethoxy)benzoyl!-2-aryl-6-hydroxybenzo ?b!thiophenes 12 1995
* 5,599,822 Methods for minimizing bone loss 8 1995
* 5,574,190 Naphthyl compounds, intermediates, compositions, and methods 14 1995
* 5,567,712 Naphthyl compounds, intermediates, compositions and methods 6 1995
6,545,027 Methods of modulating NF-kB transcription factor 0 1995
6,444,688 Compounds and compositions with nitrogen-containing non-basic side chains 2 1995
6,372,945 Process for the synthesis of vinyl sulfoxides 0 1995
* 5,606,075 Process for the synthesis of benzo[b]thiophenes 3 1995
* 5,606,076 Process for the synthesis of benzo[b]thiophenes 2 1995
* 5,596,106 Cannabinoid receptor antagonists 52 1995
* 5,569,772 Process for the synthesis of benzo[b]thiophenes 2 1995
* 5,567,828 Compounds and compositions with nitrogen-containing non-basic side 25 1995
* 5,532,254 Modulation of calcium channels using benzothiophenes 11 1995
* 5,514,826 Vinyl sulfenic acid derivatives 3 1995
* 5,512,701 Process for the synthesis of vinyl sulfenic acid derivatives 2 1995
* 5,624,940 Aqueous solution inclusion complexes of benzothiophene compounds with water soluble cyclodextrins, and pharmaceutical formulations and methods thereof 9 1995
* 5,808,061 Intermediates and processes for preparing benzothiophene compounds 2 1995
* 5,512,684 Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophenes 3 1995
* 5,556,876 Methods for lowering serum cholesterol 5 1995
* 5,552,433 Method for lowering serum cholesterol 8 1995
* 5,521,172 Methods for lowering serum cholesterol 7 1995
* 5,700,815 Methods of increasing thrombomodulin expression 5 1995
* 5,576,337 Method of treating anxiety by inhibiting physiological conditions associated with an excess of neuropeptide Y 13 1995
* 5,567,714 Methods of treating obesity by inhibiting physiological conditions associated with an excess of neuropeptide Y 20 1995
* 5,567,715 Methods of treating depression by inhibiting physiological conditions associated with an excess of neuropeptide Y 2 1995
* 5,504,094 Use of bengothiophenls to treat pain due to an excess of neuropeptide y 16 1995
6,274,601 Methods of inhibiting ulcerative mucositis 2 1995
6,451,817 Alpha-substituted-1-benzyl-napthyls 0 1995
6,417,199 3-benzyl-benzothiophenes 2 1995
* 5,705,507 Aplha-substituted-3-benzyl-benzofurans 2 1995
* 5,712,390 Process for preparing 2-substituted benzo ?B! Thiophene compounds and intermediates thereof 0 1995
* 5,710,285 Process for preparing 2-substituted benzo?B!thiophene compounds and intermediates thereof 3 1995
* 5,691,353 Method of inhibiting aortal smooth muscle cell proliferation using naphthyl compounds 4 1995
* 5,750,688 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 1 1996
* 5,652,259 Methods of inhibiting Alzheimer's disease 11 1996
6,440,958 Acrylic and propionic acid compounds, intermediates, processes, compositions, and methods 2 1996
* 6,124,311 Methods for treating resistant tumors 8 1996
* 6,121,292 Methods for reversing multidrug resistance 1 1996
* 5,631,247 Compounds and compositions with nitrogen-containing non-basic side chains 3 1996
* 5,811,421 Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods 4 1996
* 5,646,137 Combination treatment for osteoporosis 20 1996
* 5,792,870 2-amino-3-aroyl-benzo?.beta.!thiophenes and methods for preparing and using same to produce 6-hdyroxy-2-(4-hydroxyphenyl)-3-?4-(2-aminoethoxy)-benzoyl!benzo?.beta.!thiophenes 1 1996
* 5,691,355 Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs 11 1996
* 5,747,524 Cannabinoid receptor antagonists 47 1996
6,432,982 Benzothiophenes, and formulations and methods using same 2 1997
* 5,747,510 Pharmaceutical unit dosage formulations 20 1997
* 5,731,342 Benzothiophenes, formulations containing same, and methods 13 1997
* 5,688,796 Heterocyclic substituted benzothiophenes, compositions, and methods 5 1997
* 6,110,942 Method for minimizing the uterotrophic effect of droloxifene 0 1997
6,432,983 Benzothiophene compounds intermediates processes and methods of use 2 1997
* 5,760,030 Benzothiophene compounds and methods of use 5 1997
6,713,494 Amorphous benzothiophenes, methods of preparation and methods of use 4 1997
6,599,920 Naphthalene compounds, intermediates, formulations, and methods 2 1997
* 5,958,916 Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods 7 1997
6,593,345 Naphthyl compounds, intermediates, compositions, and methods of use 2 1997
* 5,998,442 Benzo [B] thiophene compounds, and compositions for treating bone loss, and hyperlipidemia 2 1997
* 5,843,965 Benzo ?B! thiophene compounds, intermediates, processes, compositions, and methods 3 1997
* 6,017,914 Benzo[b]thiophene compounds, intermediates, formulations, and methods 2 1997
* 5,948,796 Benzo?B!thiophene compounds, intermediates, formulations, and methods 2 1997
* 5,929,090 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods 5 1997
* 5,856,341 Benzo ?B! indeno ?2,1-D! thiophene compounds, intermediates, processes, compositions and methods 4 1997
* 5,843,963 Benzothiophene compounds, intermediates, processes, compositions, and methods 2 1997
* 5,834,488 Dihydrobenzo ?B! indeno ?2, 1-D! thiophene compounds, intermediates, processes, compositions and methods 2 1997
* 5,792,762 Dihydrobenzofluorene compounds, intermediates, compositions and methods 1 1997
* 5,981,570 Benzothiophene compounds, compositions, and methods 2 1997
* 5,977,383 Process for the synthesis of benzothiophenes 1 1997
* 5,889,000 Naphthofluorene compounds, intermediates, compositions and methods 0 1997
* 5,958,917 Benzofluorene compounds, intermediates, compositions, and methods 1 1997
* 5,821,253 Tetrahydrobenzo?a!fluorene compounds and methods of use 0 1997
* 5,916,916 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods 11 1997
6,350,884 Acrylic and propionic acid compounds, intermediates, processes, compositions, and method 1 1997
* 5,998,443 Phosphorous containing benzothiophenes for treating estrogen deficiency 0 1997
* 5,985,897 Benzothiphene compounds, intermediates, compositions, and methods 3 1997
* 5,952,350 Naphthyl compounds and compositions, as estrogen receptor binding agents 4 1997
* 5,843,940 Benzothiophene compounds, compositions, and method 3 1997
* 5,969,157 Process for the synthesis of benzothiophenes 5 1997
* 5,955,608 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents 0 1998
* 6,025,373 Methods for reducing fibrinogen 0 1998
* 5,994,370 Indene compounds having activity as SERMS 0 1998
* 6,090,949 Processes for preparing benzothiophenes 0 1998
* 6,043,360 Intermediates and a process for preparing benzo[B]thiophenes 0 1998
* 6,025,495 Regioselective alkylation process for preparing substituted benzo[b]thiophenes 0 1998
* 6,018,056 Intermediates and processes for preparing benzo (b) thiophenes 1 1998
* 5,994,547 Process for preparing benzo[b]thiophenes 0 1998
* 6,121,293 Benzothiophene compounds, compositions, and methods 3 1998
* 5,977,098 Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods 1 1998
* 5,977,382 Benzo[b]thiophene compounds, intermediates, processes, compositions, and methods 0 1998
* 5,952,513 Benzo?b! thiophene compounds 1 1998
* 6,075,146 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals 1 1998
* 6,020,513 Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods 0 1998
6,509,356 1-(4-(Substituted alkoxy)benzyl)naphthalene compounds having estrogen inhibitory activity 5 1998
* 6,103,740 Methods for lowering platelet counts 4 1998
* 6,090,843 Benzothiophenes compounds which have useful pharmaceutical activity 4 1998
* 6,008,232 Methods for preventing headaches 3 1998
* 5,908,859 Benzothiophenes for inhibiting hyperlipidemia 5 1998
* 6,008,377 Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes 1 1998
* 6,075,151 Benzothiophene compounds, intermediates, processes, compositions, and methods 5 1998
* 5,990,129 Methods for regulating trkA expression 2 1998
* 6,060,488 Benzothiophenes for treating estrogen deficiency 6 1998
6,403,614 Benzothiophenes 0 1998
* 6,133,458 Benzo[B]indeno[2, 1-D]thiophene compounds, intermediates, compositions, and methods 2 1998
* 5,959,103 Naphthofluorene compounds, intermediates, compositions, and methods 0 1998
6,353,003 Method for reducing levels of homocysteine and C-reactive protein 5 1999
6,355,632 Naphthyl compounds, intermediates, compositions, and methods 1 2000
6,921,827 Process for preparing 3-aryl-benzo{b} thiophenes 0 2001
RE39049 Methods for inhibiting bone loss 6 2003
* RE39050 Methods of use for inhibiting bone loss and lowering serum cholesterol 5 2003
RE38968 Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride 7 2003
6,906,086 Methods for inhibiting bone loss 4 2003
7,012,153 Process for preparing benzoic acids 1 2003
6,894,064 Benzothiophenes, formulations containing same, and methods 5 2004
7,105,541 Naphthyl compounds, intermediates, compositions, and methods of use 0 2004
8,030,330 Benzothiophenes, formulations containing same, and methods 0 2010
 
PONIARD PHARMACEUTICALS, INC. (12)
* 5,847,007 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 21 1994
* 5,770,609 Prevention and treatment of cardiovascular pathologies 95 1995
* 5,595,722 Method for identifying an agent which increases TGF-beta levels 85 1995
* 6,166,090 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 2 1997
* 5,945,456 Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells 36 1997
6,197,789 Prevention and treatment of cardiovascular pathologies with tamoxifen analogues 25 1997
* 6,117,911 Compounds and therapies for the prevention of vascular and non-vascular pathologies 68 1998
6,251,920 Prevention and treatment of cardiovascular pathologies 15 1998
6,262,079 Prevention and treatment of cardiovascular pathologies 22 1999
6,410,587 Compounds and therapies for the prevention of vascular and non-vascular pathologies 23 2000
7,084,171 Compounds and therapies for the prevention of vascular and non-vascular pathologies 13 2004
7,511,070 Compounds and therapies for the prevention of vascular and non-vascular pathologies 1 2005
 
BOSTON SCIENTIFIC SCIMED, INC. (6)
6,491,938 Therapeutic inhibitor of vascular smooth muscle cells 92 2001
8,067,022 Therapeutic inhibitor of vascular smooth muscle cells 0 2001
6,569,441 Therapeutic inhibitor of vascular smooth muscle cells 80 2001
7,625,410 Stent device and method 0 2006
8,158,670 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
8,097,642 Therapeutic inhibitor of vascular smooth muscle cells 0 2007
 
PFIZER INC. (4)
* 5,589,482 Benzo-thiophene estrogen agonists to treat prostatic hyperplasia 6 1994
6,441,193 Estrogen agonists/antagonists 10 1999
6,911,456 Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions 1 2002
RE39558 5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis 0 2004
 
PFIZER PRODUCTS INC. (2)
* 6,204,286 Estrogen agonists/antagonists 22 1997
* 6,153,622 Estrogen agonists/antagonists 23 1998
 
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (1)
* 5,470,854 2-phenylbenzo[B]furans, process for their manufacture and pharmaceutical preparations containing them 68 1994
 
BAYLOR UNIVERSITY (1)
* 5,886,025 Anti-mitotic agents which inhibit tubulin polymerization 14 1997
 
CIPLA LIMITED (1)
8,344,149 Crystalline form of benzothiophene compound and process for preparation thereof 0 2007
 
Effik SCA BAT (1)
* 6,165,491 Pharmaceutical composition based on estrogen and progesterone 15 1998
 
TOYOTA JIDOSHA KABUSHIKI KAISHA (1)
* 5,852,193 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals 2 1998
 
WYETH (1)
* 5,827,876 Inhibition of bone loss by 3-(4-acrylamidobenzoyl) benzo?b!-thiophenes 8 1997
 
Other [Check patent profile for assignment information] (2)
6,268,361 Naphthyl compounds, intermediates, compositions, and methods 3 1995
8,501,690 Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue 1 2010
* Cited By Examiner