Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
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United States of America Patent
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Jun 21, 1983
Grant Date -
N/A
app pub date -
Mar 26, 1982
filing date -
Mar 26, 1982
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being one or more hydroxypropylmethylcelluloses or a mixture of one or more hydroxypropylmethylcelluloses and up to 30% by weight of the mixture of methylcellulose, sodium carboxymethylcellulose and/or other cellulose ether, and wherein at least one of the hydroxypropylmethylcelluloses has a methoxy content of 16-24 weight-%, a hydroxypropoxyl content of 4-32 weight-% and a number average molecular weight of at least 50,000 and wherein the carrier base material constitutes less than about one third of the weight of the solid unit dosage form.
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