Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants

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United States of America Patent

PATENT NO 4395394
SERIAL NO

06314240

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Abstract

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N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)-propanediamines and N,N-higher alkyl-xylylenediamines formulated with fat or lipid emulsions are useful as vaccine adjuvants of low toxicity. These compositions are useful in conjunction with known immunological substances in order to induce or enhance the immunogenic response. Preferred compositions employ N,N-higher alkyl-N',N'-bis(2-hydroxyethyl)propanediamines, particularly N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)-propanediamine in Intralipid.

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Patent Owner(s)

  • PFIZER INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hemsworth, George R Sparta, NJ 2 17
Jensen, Keith E Waterford, CT 2 17
Wolff, III John S River Vale, NJ 2 17

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