Adult schistosome worm-derived antigenic substance and method of obtaining same
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United States of America Patent
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Aug 2, 1983
Grant Date -
N/A
app pub date -
Dec 18, 1980
filing date -
Dec 18, 1980
priority date (Note) -
Expired
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Abstract
An extract of adult Schistosome mansoni worms, obtained by incubation in 0.15 M sodium chloride-sodium phosphate buffer (pH 6.8), contains protein, carbohydrates, and nucleic acid and/or by-products of the latter component and resolves into four major fractions by gel chromatography in G-100 and G-200 Sephadex columns. Immunodiffusion tests with rabbit anti-total extract serum reveal three precipitation lines corresponding to fractions I and II, and one with III or IV. Rabbits immunized with this total extract are found to be totally or partially (at least 77%) resistant to a challenge infection. The saline extract antigenic material is an effective vaccine for the treatment and immunization of schistosomiasis and other schistosome infections.
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