Semi-synthesis of human insulin

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United States of America Patent

PATENT NO 4401757
SERIAL NO

06336072

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Abstract

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A process for preparing B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1.

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Patent Owner(s)

Patent OwnerAddress
SHIONOGI & CO LTD1-8 DOSHOMACHI 3-CHOME CHUO-KU OSAKA-SHI OSAKA 541-0045

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Masaki, Takeharu Ibaraki, JP 3 19
Morihara, Kazuyuki Osaka, JP 8 52
Oka, Tatsushi Osaka, JP 5 39
Soejima, Masami Tsuchiura, JP 3 19

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