Method of binding a biologically active material to a carrier containing hydroxyl groups
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United States of America Patent
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-
Oct 25, 1983
Grant Date -
N/A
app pub date -
Nov 12, 1981
filing date -
Nov 19, 1980
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Biologically active material such as an enzyme is bonded to a carrier containing hydroxyl groups by binding an isocyanate compound to the carrier and bonding the biologically active material to the bound isocyanate compound. Binding of the isocyanate compound to the carrier is achieved with the use of a non-toxic titanium based compound which catalyzes the formation of urethane bonds. The preferred non-toxic based titanium compound is an orthotitanium acid ester such as tetrabutyltitanate.
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