Chemotherapeutically active maytansinoids: treflorine, trenudine, and N-methyltrenudone
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United States of America Patent
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Nov 29, 1983
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N/A
app pub date -
Sep 29, 1982
filing date -
Sep 29, 1982
priority date (Note) -
Expired
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Abstract
A novel group of maytansinoid compounds has been discovered in the seed tissue of Trewia nudiflora. They are represented by the general formula ##STR1## and are uniquely characterized by a 12-membered ring joining C-3 and the amide nitrogen at C-18, and also by a distinguishing methoxy group on the C-15 carbon. These isolates have proven to be effective in causing the remission of one or more types of malignancies.
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