Process for the preparation of reactive, couplable derivatives of the thyroid hormones
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United States of America Patent
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Dec 27, 1983
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N/A
app pub date -
Sep 30, 1981
filing date -
Oct 7, 1980
priority date (Note) -
Expired
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Abstract
Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T.sub.3) and 3,3',5,5'-tetraiodothyronine (T.sub.4) by reaction with reactive carboxylic acid derivatives, which process comprises sylylating all the functional groups of the thyroid hormone by reaction with a reactive triorganosylyl derivative and then reacting the persylylated derivative of the thyroid hormone thus obtained with an activated carboxylic acid derivative.
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