Cholesterol matrix delivery system for sustained release of macromolecules
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United States of America Patent
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Jun 5, 1984
Grant Date -
N/A
app pub date -
Dec 3, 1982
filing date -
Dec 3, 1982
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Delivery systems for releasing macromolecular active agents to a body site at a controlled rate for a prolonged period of time, comprising a cholesteric matrix permeable to passage of the macromolecular active agent by diffusion, are disclosed. The cholesteric matrix comprises cholesterol powder and cholesterol prills optionally in combination with a binding agent and a lubricating agent. The macromolecular active agent is dispersed throughout the matrix; macromolecules suitable for release from this delivery system have molecular weights of about 1300 to about 75,000 and are at least very slightly soluble in water.
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