(2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
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United States of America Patent
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Aug 7, 1984
Grant Date -
N/A
app pub date -
Apr 10, 1981
filing date -
Apr 10, 1981
priority date (Note) -
Expired
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Abstract
3'-Deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double stranded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes Simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.
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