US Patent No: 4,472,840

Number of patents in Portfolio can not be more than 2000

Method of inducing osseous formation by implanting bone graft material

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Abstract

Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone particles (DBP) and bone morphogenetic protein have demonstrated the ability to induce the formation of osseous tissue in animal and human experiments. Reconstituted collagen conjugate is highly biocapatible and can be fabricated in a variety of configurations, especially as a sponge. This material can be used as a grafting implant in plastic and reconstructive surgery, periodontal bone grafting, and in endodontic procedures. Structural durability is enhanced by cross-linking with glutaraldehyde which is also used to sterilize and disinfect the collagen conjugate prior to implantation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
COLLAGENIX CORPORATIONIRVINE, CA4
GENSCI ORTHOBIOLOGICS, INC.IRVINE, CA3

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jefferies, Steven R Milford, DE 40 1165

Cited Art

Patent Info (Count) # Cites Year
 
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MERCK PATENT GMBH (1)
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Patent Citation Ranking

Forward Cites

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Other [Check patent profile for assignment information] (5)
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