US Patent No: 4,474,893

Number of patents in Portfolio can not be more than 2000

Recombinant monoclonal antibodies

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Abstract

Antibodies having binding affinity for two desired antigens, hereinafter "recombinant monoclonal antibodies"; recombinant monoclonal antibodies produced by a quadroma cell or a trioma cell; and methods for producing recombinant monoclonal antibodies by means of a quadroma cell or a trioma cell, wherein a quadroma cell is the fusion product of a hybridoma cell which produces an antibody having specific binding affinity to one desired antigen and a hybridoma cell which produces an antibody having specific binding affinity for another desired antigen, and wherein a trioma cell is the fusion product of a hybridoma cell which produces an antibody having specific binding affinity to one desired antigen and a lymphocyte which produces an antibody having specific binding affinity to another desired antigen.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMAUSTIN, TX2784

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Reading, Christopher L San Diego, CA 39 527

Cited Art

Patent Info (Count) # Cites Year
 
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4,356,117 Chemical modifications of proteins which induce new receptor specificities and therefore elicit new effects in cells 8 1980
 
BRITISH TECHNOLOGY GROUP LIMITED (1)
4,350,683 Antibody production from hybrid cell line 60 1980
 
GOLDENBERG, MILTON DAVID (1)
4,348,376 Tumor localization and therapy with labeled anti-CEA antibody 100 1980
 
HYBRITECH INCORPORATED (1)
4,376,110 Immunometric assays using monoclonal antibodies 682 1980
 
IMMUNEX CORPORATION (1)
4,411,993 Hybridoma antibody which inhibits interleukin 2 activity 52 1981
 
MASSACHUSETTS GENERAL HOSPITAL (1)
4,271,145 Process for producing antibodies to hepatitis virus and cell lines therefor 48 1979
 
ORTHO DIAGNOSTIC SYSTEMS INC. (1)
4,284,412 Method and apparatus for automated identification and enumeration of specified blood cell subclasses 137 1979
 
ORTHO PHARMACEUTICAL CORPORATION (1)
4,361,549 Complement-fixing monoclonal antibody to human T cells, and methods of preparing same 30 1979
 
PALO ALTO MEDICAL FOUNDATION (1)
4,361,647 Sandwich immunoassay and compositions for use therein 18 1980
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
4,381,292 Anti-human T-lymphocyte monoclonal antibody 24 1980
 
THE WISTAR INSTITUTE (1)
4,196,265 Method of producing antibodies 243 1978
 
WISTAR INSTITUTE, THE, A CORP. OF PA (1)
4,349,528 Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen 39 1979

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
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7,541,034 Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors 1 1998
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (6)
5,837,263 Leptospira membrane proteins 2 1995
6,140,083 Leptospiral outer membrane protein, LipL46 0 1998
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HEALTH RESEARCH, INC. (5)
7,053,210 Efficient synthesis of pyropheophorbide a and its derivatives 3 2003
7,501,509 Water soluble tetrapyrollic photosensitizers for photodynamic therapy 2 2006
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7,084,257 Fully human antibody Fab fragments with human interferon-gamma neutralizing activity 27 2001
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7,371,381 Anti-galanin antibodies and uses thereof 0 2004
7,928,074 Combination therapy with co-stimulatory factors 0 2008
 
GENENTECH, INC. (4)
5,670,626 Allergen-specific human IgA monoclonal antibodies for mucosal administration 13 1994
5,635,601 Beta-8 integrin subunit antibodies 3 1995
7,041,293 HIV env antibodies 0 1998
7,258,983 Cardiotrophin-1 compositions and methods for the treatment of tumor 0 2004
 
UNIVERSITY OF ROCHESTER (4)
7,563,882 Polynucleotides encoding antibodies that bind to the C35 polypeptide 16 2003
7,750,125 Antibodies that bind to the C35 polypeptide 11 2007
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BIONOMICS LIMITED (3)
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BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (3)
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BOSTON BIOMEDICAL RESEARCH INSTITUTE (3)
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5,523,210 Bispecific antibody determinants 4 1992
5,501,854 Hybrid reagents capable of selectively releasing molecules into cells 4 1992
 
CELLDEX RESEARCH CORPORATION (3)
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MILANO ACQUISITION CORP. (3)
5,858,683 Methods and compositions for the detection of cervical cancer 10 1996
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INSTITUT PASTEUR (2)
6,025,143 Antibodies directed against peptides derived from the SMR1 polypeptide 6 1995
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QUEEN'S UNIVERSITY AT KINGSTON (2)
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SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH (2)
5,712,370 Erythropoietin (EPO) peptides and antibodies directed against these 4 1994
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7,807,168 Selection of human TNFα specific antibodies 0 2008
 
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