Immunoglobulin half-molecules and process for producing hybrid antibodies
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United States of America Patent
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Oct 30, 1984
Grant Date -
N/A
app pub date -
May 5, 1982
filing date -
May 5, 1982
priority date (Note) -
Expired
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Abstract
A process for preparing covalent hybrid antibodies is provided. These antibodies are obtained by the ordered covalent hybridization of intact immunoglobulin molecules. The generation of half-molecules from different IgG antibodies by reductive or S-sulfonation selective cleavage is followed by the ordered association of the different half-molecules. The pure covalent hybrid antibodies as new substances are also provided along with IgG half-molecules.
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