Use of phosphotriester intermediates for preparation of functionalized liposomes
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United States of America Patent
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Oct 30, 1984
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N/A
app pub date -
Jul 9, 1982
filing date -
Jul 9, 1982
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Expired
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Abstract
A method of forming an analyte-functionalized liposome for use in immunoassay techniques employs a phosphotriester intermediate of a phospholipid derivatized with the desired analyte in a process of forming a liposome which is functionalized on its outer surface with the analyte and which carries an enzyme marker. The method is also used to functionalize the liposome with a ligand which acts as a leash between the analyte and the liposome. Liposomes produced by the method include penicillin-G-functionalized liposome.
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