Method of conjugating oligopeptides
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United States of America Patent
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Dec 11, 1984
Grant Date -
N/A
app pub date -
Jul 9, 1982
filing date -
Jul 9, 1982
priority date (Note) -
Expired
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Abstract
Novel methods are provided for preparing peptide compounds involving functionalizing an available amino group with a carboxy group, esterifying the carboxy group with an hydroxylic compound which forms an ester which is stable under the conditions of cleavage of the oligopeptide from said resin, but which ester is capable of forming a peptide bond with an amino group in an aqueous medium, and without separation, either allowing the oligopeptide to react with itself or with a polypeptide compound.
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