Plasmid having temperature dependent plasmid copy number

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United States of America Patent

PATENT NO 4487835
SERIAL NO

06214423

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Gene products of plasmid DNA, such as proteins, are prepared in high yields by cultivating bacteria carrying a plasmid which shows a controlled constant plasmid copy number at one temperature and a much higher or totally uncontrolled copy number at a different temperature. The plasmid may be prepared by recombinant DNA technique using a cloning vector showing the temperature dependent plasmid copy number pattern.

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NYCOMED DANMARK A/S4000 ROSKILDE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gustaffson, Petter Odense 1 9
Molin, Soeren Odense, DK 3 28
Nordstro/, m Kurt Odense, DK 1 9
Uhlin, Bernt E Odense, DK 4 71

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