Nitroglycerin-containing polymeric matrix for sustained release on topical application
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United States of America Patent
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Aug 6, 1985
Issued Date -
N/A
app pub date -
Aug 30, 1984
filing date -
Dec 16, 1980
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer provides a polymeric matrix which gradually releases nitroglycerin upon application to the skin of a patient in the form of a film, gel or ointment. The water-insoluble vinylpyrrolidone polymer may be an uncrosslinked copolymer or a crosslinked homopolymer or copolymer. The polymer provides increased stability and reduced volatility of the nitroglycerin while permitting slow and sustained release of the drug upon topical application to the skin.
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