Water soluble fraction capable of controlling the immune reactions of a host against allogenic cells or tissue, the pharmaceutical compositions containing said fraction and a process for preparing the latter
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United States of America Patent
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Sep 10, 1985
Grant Date -
N/A
app pub date -
Jul 2, 1981
filing date -
Nov 22, 1979
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Water soluble biologically active fraction obtainable from the physiologically inter-cellular medium bone-marrow and process for preparing said fraction and the pharmaceutical compositions containing said fraction. The characteristics are notably the following: it is substantially free of the inhibitors having molecular weights lower than 30,000; it is lyophilizable without loss of biological properties; it exhibits the biological activities in the form of a solution having a pH of at least 7; it stimulates H-thymidin incorporation by bone-marrow cells in vitro and in vivo; the water soluble fraction is capable of controlling the immune reactions of a host against allogenic cells or tissue.
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