Process for preparing biaryl compounds via coupling of an arylamine with an arene
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United States of America Patent
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Sep 17, 1985
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N/A
app pub date -
Jul 20, 1983
filing date -
Jul 23, 1982
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Expired
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Abstract
Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.
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