Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
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United States of America Patent
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Nov 19, 1985
Issued Date -
N/A
app pub date -
Jan 28, 1983
filing date -
Jan 9, 1981
priority date (Note) -
Expired
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Abstract
An immunoglobulin is provided which consists essentially of a mono-specific, hetero-molecular antibody which is mono-specific to a single antigenic or allergenic determinant. The antibody is specific to the H-epitope of a protein antigen or allergen. The H-epitope is defined by a sequence of at least six amino acids corresponding to the sequence of such amino acids in the protein antigen or allergen where the greatest local average hydrophilicity of the protein antigen or allergen is found.
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