Matrix composition for transdermal therapeutic system
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United States of America Patent
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Dec 17, 1985
Grant Date -
N/A
app pub date -
May 4, 1983
filing date -
May 4, 1983
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at least about 6% CSD, have a MO/PIB of at least 1.0 and a viscosity of at least 1.5.times.10.sup.7 poises. Preferred systems for dispensing clonidine have a clonidine permeability of at least 1.0.times.10.sup.-4 .mu.g/cm sec and a MO/PIB of at least 1.2.
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