Infection-resistant materials and method of making same through use of sulfonamides
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United States of America Patent
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Apr 8, 1986
Grant Date -
N/A
app pub date -
Apr 30, 1984
filing date -
Apr 30, 1984
priority date (Note) -
Expired
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Abstract
Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as metal salts of sulfonamides and other antimicrobials or antibacterials, such as piperacillin. In particular illustrative embodiments, silver sulfadiazine is complexed by novel techniques with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during, or after, surgery or implantation of a device.
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