Inhibition of diarrhea induced by Escherichia coli heat-stable enterotoxin
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United States of America Patent
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May 6, 1986
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N/A
app pub date -
Feb 7, 1983
filing date -
Feb 7, 1983
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Expired
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Abstract
Substantially nontoxic materials such as cysteamine constituting a source of sulfhydryl groups are useful in inhibiting diarrhea induced by Escherichia coli heat-stable enterotoxin. Such materials block ST-induced secretion prior to the formation of cyclic GMP without interference with normal basal activity or metabolism and may inactivate ST itself by breaking disulfide bridges.
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