3-(2-(4-phenylpiperazinylethyl)anilino)-isobenzofuranones, their method of preparation and their use as antihypertensive and antiallergic drugs

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United States of America Patent

PATENT NO 4590193
SERIAL NO

06517653

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Abstract

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This invention relates to 3-(2-(4-phenylpiperazinylethyl)anilino)-isobenzofuranones, their method of preparation and their use in the treatment of conditions such as hypertension, and allergies. These compounds are characterized by the formula: ##STR1## in which R.sub.1 may be one or more substituents located at the ortho, meta, or para positions selected from the group of H, CH.sub.3, CF.sub.3, F, Cl and OCH.sub.3 ; R.sub.2 and R.sub.3 are the same or different and are H or OCH.sub.3. These compounds are in the form of free bases or their pharmaceutically safe salts. They can be obtained by a reaction between a 2-(phenylpiperazinylethyl) aniline and an aromatic aldehyde having an acid function at the ortho position of the carboxaldehyde function. These derivatives are useful for the treatment of hypertension and allergic conditions.

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Patent Owner(s)

Patent OwnerAddress
SOCIETE CORTIAL S A7 RUE DE 1'ARMORIQUE PARIS 75015

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Creuzet, Marie-Helene Bordeaux, FR 13 53
Feniou, Claude Pessac, FR 17 61
Guichard, Francoise Bordeaux, FR 7 36
Pontagnier, Henri Pessac, FR 15 68
Prat, Gisele Talence, FR 15 71

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