Process and materials for producing soluble biological mediators from white blood cells
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United States of America Patent
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May 27, 1986
Grant Date -
N/A
app pub date -
Dec 2, 1982
filing date -
Dec 2, 1982
priority date (Note) -
Expired
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Abstract
A process and cellular system for producing soluble biological mediators, including cytokines, lymphokines, monokines and interferons, and mRNA therefor, from white blood cells is provided. The process involves treating white blood cells with a mitogenic or antigenic agent in the presence of a controlled amount of red blood cells. Increases in production of the soluble biological mediator, gamma interferon, on the order of 5 to 10 fold have been achieved by maintaining the ratio of red blood cells to white blood cells between 10 to 1 and about 50 to 1. The process is particularly useful in producing HuIFN-.gamma. with PHA-P.
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