Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates
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United States of America Patent
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May 27, 1986
Issued Date -
N/A
app pub date -
Apr 30, 1984
filing date -
Oct 7, 1983
priority date (Note) -
Expired
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Abstract
Oligonucleoside-3'-alkyl or aryl phosphonates are prepared by condensing (i) a 5'-protected nucleoside 3'-alkyl or aryl phosphonic imidazolide with (ii) a nucleoside or oligomer which is attached through its 3'-position to a polymer support. The process is advantageously carried out in the presence of tetrazole.
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