Transcutaneous application of nicotine
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United States of America Patent
Stats
-
Jul 1, 1986
Grant Date -
N/A
app pub date -
Jan 23, 1985
filing date -
Jan 23, 1985
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Percutaneous administration of nicotine in a dose approximating the dose delivered by a variety of nicotine-containing products, such as cigarettes, cigars, snuff and chewing tobacco, is carried out using an occlusive pad. The nicotine is delivered so as to mimic the pharmacological effects of nicotine provided by the conventional use of tobacco, and a therapeutic function is achieved by reducing or eliminating the need for the tobacco product. A suitable transdermal application pad comprises a reservoir for liquid nicotine base to be affixed to the skin in a variety of places. Due to the high lipid solubility and resultant high skin permeability of nicotine, vehicles or solvents are not generally needed to enhance dermal absorption.
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