Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
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United States of America Patent
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Jul 8, 1986
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N/A
app pub date -
Mar 9, 1984
filing date -
Mar 9, 1984
priority date (Note) -
Expired
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Abstract
Chemically synthesized polypeptides include amino acid residue sequences that substantially correspond to the amino acid residue sequences of T cell and B cell determinant portions of a natural, pathogen-related protein, in particular, a hepatitis B virus surface antigen (HBsAg). When administered to a host alone, as polymers or as carrier-bound conjugates, the polypeptides induce the proliferation of thymus-derived cells in hosts primed against hepatitis B virus.
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